Recombinant Human FMOD Protein, Fc-tagged

• Cat.No.: FMOD-3993H
• Product Overview: Recombinant Human FMOD(Met1-Ile376) fused with the Fc region of human IgG1 at C-terminal was expressed in HEK293.

Specification

• Description: Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants.
• Source: HEK293
• Species: Human
• Tag: Fc
• Predicted N Terminal: Gln 19
• Form: Lyophilized from sterile PBS, pH 7.4.
  1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
• Molecular Mass: The recombinant human FMOD comprises 599 amino acids and has a predicted molecular mass of 68.2 kDa.
• Protein length: Met1-Ile376
• Endotoxin: <1.0 EU per μg protein as determined by the LAL method.
• Purity: > 90 % as determined by SDS-PAGE.
• Stability: Samples are stable for up to twelve months from date of receipt at -70 centigrade
• Storage: Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
  Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

Gene Information

• Gene Name: FMOD fibromodulin [ Homo sapiens ]
• Official Symbol: FMOD
• Synonyms: FMOD; fibromodulin; fibromodulin proteoglycan; SLRR2E; FM; KSPG fibromodulin; collagen-binding 59 kDa protein; keratan sulfate proteoglycan fibromodulin
• Gene ID: 2331
• mRNA Refseq: NM_002023
• Protein Refseq: NP_002014
• MIM: 600245
• UniProt ID: Q06828