FMOD
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Official Full Name
fibromodulin -
Overview
Fibromodulin is a member of a family of small interstitial proteoglycans, containing a central region composed of leucine-rich repeats with 4 keratan sulfate chains flanked by disulfide-bonded terminal domains. It may participate in the assembly of the extracellular matrix as it interacts with type I and type II collagen fibrils and inhibits fibrillogenesis in vitro. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. -
Synonyms
FMOD;fibromodulin;fibromodulin proteoglycan;SLRR2E;Collagen binding 59 kDa protein;Fibromodulin precursor;Keratan sulfate proteoglycan fibromodulin;KSPG fibromodulin;FM;OTTHUMP00000034098;collagen-binding 59 kDa protein
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- Chicken
- E.coli
- Mammalian cells
- Mammalian Cell
- HEK293
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Fc
- Myc&DDK
- Non
- Flag
- His&Fc&Avi
Involved Pathway
FMOD involved in several pathways and played different roles in them. We selected most pathways FMOD participated on our site, such as Defective B4GALT1 causes B4GALT1-CDG (CDG-2d),Defective CHST6 causes MCDC1,Defective ST3GAL3 causes MCT12 and EIEE15, which may be useful for your reference. Also, other proteins which involved in the same pathway with FMOD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Defective CHST6 causes MCDC1 | OGN,ACAN,PRELP,KERA |
| Diseases associated with glycosaminoglycan metabolism | ACAN,PRELP,KERA,OGN |
| Diseases of glycosylation | PRELP,KERA,OGN,ACAN |
| Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) | KERA,ACAN,PRELP,OGN |
| Defective ST3GAL3 causes MCT12 and EIEE15 | PRELP,ACAN,OGN,KERA |
| Extracellular matrix organization | EMID2,ADAM9,FBN2,COL5A1,COL4A3,HAPLN1,ADAMTS8,ADAMTS2,ADAMTS18,ABHD1 |
| Disease | ANTXR2,PSIP1,SFTPB,TICAM1,AP2S1,TAF1L,RPL35,SUPT4H1,NMT1,JAG1 |
| ECM proteoglycans | SPARC,MUSK,ASPN,DMP1,MATN1,COL9A1,DAG1,ITGB3A,LRP4,VCANB |
Protein Function
FMOD has several biochemical functions, for example, NOT Roundabout binding,heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FMOD itself. We selected most functions FMOD had, and list some proteins which have the same functions with FMOD. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NOT Roundabout binding | OGN,FMODA,EPYC |
| heparin binding | PTPRFB,LRPAP1,CCL23,FGF2,LPL,AZU1,ABP1,WISP3,MSTN,NRP1 |
Interacting Protein
FMOD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FMOD here. Most of them are supplied by our site. Hope this information will be useful for your research of FMOD.
Dlg4;b4dyc6_human;thiF
Resources
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References
- Adini, I; Adini, A; et al. Melanocyte pigmentation inversely correlates with MCP-1 production and angiogenesis-inducing potential. FASEB JOURNAL 29:662-670(2015).
- Johnson, JS; Morscher, MA; et al. Gene Expression Differences Between Ruptured Anterior Cruciate Ligaments in Young Male and Female Subjects. JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME 97A:71-79(2015).
