Recombinant Human Fibroblast Growth Factor 23, Fc Chimera

• Cat.No.: FGF23-416H
• Product Overview: Recombinant human FGF-23 (aa 1-251) produced inHEK 293 cellsare fused at the C-terminus to the Fc portion of human IgG.

Specification

• Species: Human
• Source: Human Cells
• Tag: Fc
• Protein Length: 1-251 a.a.
• Description: FGF-23 is a member of the fibroblast growth factor (FGF) family. FGF-23 inhibits renal tubular phosphate transport. This gene was identified by its mutations associated with autosomal dominant hypophosphatemic rickets (ADHR), an inherited phosphate wasting disorder. Abnormally high level expression of FGF23 was found in oncogenic hypophosphatemic osteomalacia (OHO), a phenotypically similar disease caused by abnormal phosphate metabolism. Mutations FGF23 have also been shown to cause familial tumoral calcinosis with hyperphosphatemia.
• Source/Host: HEK 293 cells.
• Purity: ≥90% (SDS-PAGE).
• Formulation: Liquid. 0.2μm-filtered solution in PBS.
• Concentration: 1mg/ml.
• Endotoxin Content: <1EU/µg protein (LAL-test).
• Long Term Storage: -20°C.
• Use/Stability: Working aliquots are stable for up to 3 months when stored at -20°C.
• Handling: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

Gene Information

• Gene Name: FGF23 fibroblast growth factor 23 [ Homo sapiens ]
• Synonyms: FGF23; fibroblast growth factor 23; ADHR; HYPF; HPDR2; PHPTC; FGF-23; Tumor-derived hypophosphatemia-inducing factor; Phosphatonin; UNQ3027/PRO9828; Fibroblast growth factor 23 N-terminal peptide; Fibroblast growth factor 23 C-terminal peptide; tumor-derived hypophosphatemia inducing factor
• Gene ID: 8074
• mRNA Refseq: NM_020638
• Protein Refseq: NP_065689
• MIM: 605380
• UniProt ID: Q9GZV9
• Chromosome Location: 12p13.3
• Pathway: MAPK signaling pathway; Melanoma; Pathways in cancer; Regulation of actin cytoskeleton; Signaling by FGFR
• Function: growth factor activity