Recombinant Human FCGRT Protein, Ala24-Ser297, C-6×His tagged

• Cat.No.: FCGRT-33H
• Product Overview: Recombinant Human FCGRT Protein, Ala24-Ser297, with a C-terminal 6-His tag was expressed in Human embryonic kidney cell.

Specification

• Description: This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants.
• Source: HEK293
• Species: Human
• Tag: His
• Protein length: Ala24-Ser297
• Bio-activity: Measured by its binding ability in a functional ELISA. When Recombinant Human FCRN is immobilized at 2 μg/mL (100 μL/well), the concentration of biotinylated human IgG that produces 50% of the optimal binding response is approximately 2-10 μg/mL.
• Molecular Mass: Predicted Molecular Mass 31 kDa (FCRN), 10 kDa ( beta 2 Microglobulin)
  SDS-PAGE 30-36 kDa (FCRN), 10 kDa ( beta 2 Microglobulin)
• Endotoxin: <0.10 EU/μg of the protein by the LAL method.
• Purity: >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie Blue Staining.
• N-terminal Sequence Analysis: Ala24 (FCRN), Ile21 ( beta 2 Microglobulin)
• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  12 months from date of receipt, -20 to -70 centigrade as supplied.
  1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
  3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution in PBS.
• Shipping: The product is shipped at ambient temperature.
• Reconstitution: Reconstitute at 500 μg/mL in PBS.

Gene Information

• Gene Name: FCGRT Fc gamma receptor and transporter [ Homo sapiens (human) ]
• Official Symbol: FCGRT
• Synonyms: FCGRT; Fc gamma receptor and transporter; FCRN; FcgammaRn; alpha-chain; IgG receptor FcRn large subunit p51; Fc fragment of IgG receptor and transporter; Fc fragment of IgG, receptor, transporter, alpha; FcRn alpha chain; IgG Fc fragment receptor transporter alpha chain; heavy chain of the major histocompatibility complex class I-like Fc receptor; immunoglobulin receptor, intestinal, heavy chain; major histocompatibility complex class I-like Fc receptor; neonatal Fc receptor; neonatal Fc-receptor for Ig; transmembrane alpha chain of the neonatal receptor
• Gene ID: 2217
• mRNA Refseq: NM_004107
• Protein Refseq: NP_004098
• MIM: 601437
• UniProt ID: P55899