Recombinant Human FARS2, GST-tagged

• Cat.No.: FARS2-12748H
• Product Overview: Recombinant Human FARS2 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 109-451a.a.
• Description: Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. This gene encodes a phenylalanine-tRNA synthetase (PheRS) localized to the mitochondrion which consists of a single polypeptide chain, unlike the (alpha-beta)2 structure of the prokaryotic and eukaryotic cytoplasmic forms of PheRS. Structure analysis and catalytic properties indicate mitochondrial PheRSs may constitute a class of PheRS distinct from the enzymes found in prokaryotes and in the eukaryotic cytoplasm.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial [ Homo sapiens ]
• Official Symbol: FARS2
• Synonyms: FARS2; phenylalanyl-tRNA synthetase 2, mitochondrial; FARS1, phenylalanine tRNA synthetase 1 (mitochondrial); phenylalanine--tRNA ligase, mitochondrial; dJ236A3.1; phenylalanine tRNA ligase 2; mitochondrial; phenylalanine translase; dJ236A3.1 (phenylalanine-tRNA synthetase); phenylalanine tRNA ligase 2, mitochondrial; phenylalanyl-tRNA synthetase, mitochondrial; phenylalanine-tRNA synthetase 1 (mitochondrial); phenylalanine-tRNA synthetase 2 (mitochondrial); dJ520B18.2 (FARS1 (phenylalanine-tRNA synthetase)); FARS1; PheRS; HSPC320; dJ520B18.2
• Gene ID: 10667
• mRNA Refseq: NM_006567
• Protein Refseq: NP_006558
• MIM: 611592
• UniProt ID: O95363
• Chromosome Location: 6p25.1
• Pathway: Aminoacyl-tRNA biosynthesis, organism-specific biosystem; Aminoacyl-tRNA biosynthesis, conserved biosystem; Aminoacyl-tRNA biosynthesis, eukaryotes, organism-specific biosystem; Aminoacyl-tRNA biosynthesis, eukaryotes, conserved biosystem; Gene Expression, organism-specific biosystem; Mitochondrial tRNA aminoacylation, organism-specific biosystem; tRNA Aminoacylation, organism-specific biosystem
• Function: ATP binding; aminoacyl-tRNA ligase activity; ligase activity; magnesium ion binding; nucleotide binding; phenylalanine-tRNA ligase activity; tRNA binding; tRNA binding