Recombinant Human Endosulfine Alpha, His-tagged

• Cat.No.: ENSA-1838H
• Product Overview: Recombinant human ENSA fused to His-tag at N-terminus was expressed inE.coliand purified by using conventional chromatography techniques. MW = 15.5 kDa (141aa).

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: ENSA, also known as alpha endosulfine, belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein is expressed in a wide range of tissues including muscle, brain, and endocrine tissues. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes.
• Form: Liquid. In 20mM Tris buffer(pH 8.0) containing 10% glycerol, 1mM DTT.
• Purity: > 90% by SDS – PAGE.
• Concentration: 1 mg/ml (determined by BCA).
• Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MSQKQEEENP AEETGEEKQD TQEKEGILPE RAEEAKLKAK YPSLGQKPGG SDFLMKRLQK GQKYFDSGDY NMAKAKMKNK QLPSAGPDKN LVTGDHIPTP QDLPQRKSSL VTSKLAGGQV E.
• Storage: can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: ENSA endosulfine alpha [ Homo sapiens ]
• Synonyms: endosulfine alpha; MGC4319; MGC8394; ARPP-19e; MGC78563; ENSA;alpha-endosulfine
• Gene ID: 2029
• mRNA Refseq: NM_004436
• Protein Refseq: NP_004427
• MIM: 603061
• UniProt ID: O43768
• Chromosome Location: 1q21.3
• Function: ion channel inhibitor activity; protein binding; receptor binding