ENSA
-
Official Full Name
endosulfine alpha -
Overview
The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed. -
Synonyms
ENSA;endosulfine alpha;alpha-endosulfine;ARPP 19e;MGC4319;MGC8394;MGC78563;Alpha endosulfine;OTTHUMP00000032931;OTTHUMP00000032932;OTTHUMP00000034001;OTTHUMP00000034002;OTTHUMP00000034003;OTTHUMP00000034004;OTTHUMP00000034005;OTTHUMP00000034006;OTTHUMP00000218268;OTTHUMP00000218269;OTTHUMP00000218272;ARPP-19e
Recombinant Proteins
- Human
- Chicken
- Rat
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Fc
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
ENSA involved in several pathways and played different roles in them. We selected most pathways ENSA participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,M Phase, which may be useful for your reference. Also, other proteins which involved in the same pathway with ENSA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell cycle | ANAPC11,SSNA1,STAG2,GINS4,BUB1B,RCC2,FAM175A,NPM1,SPO11,HIST2H3C |
| Mitotic Prophase | SET,NEK9,CTDNEP1A,NEK7,ENSAB,TMEM188,NEK6,ENSAA,SMC2,SETA |
| Cell Cycle, Mitotic | MLF1IP,CTDNEP1,GINS2,CENPC1,CLASP1A,AURKB,TSGA14,LIN54,TMPO,NUDC |
| M Phase | CTDNEP1A,BLZF1,ENSAB,NIPBL,RANGAP1B,PMF1,CENPN,NCAPH2,MASTL,TMPO |
| MASTL Facilitates Mitotic Progression | ENSAB,ARPP19B,MASTL,ARPP19A,ARPP19,ENSAA |
Protein Function
ENSA has several biochemical functions, for example, ion channel inhibitor activity,phosphatase inhibitor activity,potassium channel inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ENSA itself. We selected most functions ENSA had, and list some proteins which have the same functions with ENSA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ion channel inhibitor activity | PDZD3,KCNMB2,STOML1,RSC1A1,KCNV1,GNB2L1 |
| protein phosphatase 2A binding | STRN4,IGBP1,STRN,AKT1,SMG5,CPD,PTPN1,MAPT,PPP2R4,HMGCR |
| protein phosphatase inhibitor activity | PPP1R27,PPP1R10,SH3RF2,PPP1R14C,PPP1R2P3,PPME1,ENSAA,PPP1R14D,DYSFIP1,PHACTR1 |
| phosphatase inhibitor activity | TESC,ARPP19,ENSAA,ANP32E,URI1 |
| potassium channel inhibitor activity | KCNK2,RASA1,PTI,CAV3,NEDD4L,KCNA5 |
| receptor binding | CAPRIN2,NRG4,FGF20B,PVRL1,AMN,CRH,TENM2,CXCL12,GFRA3,ACOX2 |
| protein binding | RELA,SHOC2,C2orf62,BUB3,FBXW11,PRPS1,AXIN1,FAT4,SH2B3,ARHGEF10 |
| protein phosphatase type 2A regulator activity | PPP2R1A,ENSAA,pab1,PPP2R5E,PPP2R5D,PPP2R2D,PPP2R3A,PPP2R2B,PPP2R2CA,PPME1 |
Interacting Protein
ENSA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ENSA here. Most of them are supplied by our site. Hope this information will be useful for your research of ENSA.
ACD;MCM3;CNKSR2;ARIH2;ENO2;RAP2A;PSEN1;KCTD15;POT1
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