Recombinant Human EMILIN1, His-tagged

• Cat.No.: EMILIN1-28554TH
• Product Overview: Recombinant fragment corresponding to amino acids 676-1016 of Human EMILIN1 with 6x His tag; 362 amino acids including tag, Predicted MWt 39.1 kDa .

Specification

• Description: This gene encodes an extracellular matrix glycoprotein that is characterized by an N-terminal microfibril interface domain, a coiled-coiled alpha-helical domain, a collagenous domain and a C-terminal globular C1q domain. The encoded protein associates with elastic fibers at the interface between elastin and microfibrils and may play a role in the development of elastic tissues including large blood vessels, dermis, heart and lung.
• Protein length: 341 amino acids
• Conjugation: HIS
• Molecular Weight: 39.100kDa inclusive of tags
• Source: E. coli
• Tissue specificity: Distributed in tissues where resilience and elastic recoil are prominent. Highest levels in the adult small intestine, aorta, lung, uterus, and appendix and in the fetal spleen, kidney, lung, and heart; intermediate expression was detected in adult liver,
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: pH: 7.40Constituent:99% PBS
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Contains 1 C1q domain.Contains 1 collagen-like domain.Contains 1 EMI domain.

Gene Information

• Gene Name: EMILIN1 elastin microfibril interfacer 1 [ Homo sapiens ]
• Official Symbol: EMILIN1
• Synonyms: EMILIN1; elastin microfibril interfacer 1; EMILIN-1; DKFZp586M121; gp115
• Gene ID: 11117
• mRNA Refseq: NM_007046
• Protein Refseq: NP_008977
• MIM: 130660
• Uniprot ID: Q9Y6C2
• Chromosome Location: 2p23.3-p23.2
• Function: extracellular matrix constituent conferring elasticity; identical protein binding; protein binding

Reviews

03/11/2023

The sensitivity and specificity of the EMILIN1 Protein have consistently delivered robust and consistent results, enhancing the efficiency and accuracy of my experimental workflows.

05/21/2019

It has consistently demonstrated high sensitivity and accuracy in detecting and quantifying target molecules, allowing for precise and reliable measurement of analytes in my experimental samples.

09/06/2018

Its versatility and reliability make it an excellent choice for research applications, and I highly recommend it to fellow scientists.

Q&As

Can EMILIN1 serve as a biomarker for neurological disorders?

Research is exploring the potential of EMILIN1 as a biomarker for certain neurological disorders, but further clinical validation is needed to establish its diagnostic utility.

Can EMILIN1 serve as a biomarker for lung diseases?

There is research interest in exploring the potential of EMILIN1 as a biomarker for lung diseases, particularly in the context of pulmonary fibrosis and related conditions.

How does EMILIN1 relate to skin disorders?

EMILIN1 is involved in the assembly and maintenance of elastic fibers in the skin, and its dysregulation has been implicated in skin disorders such as cutis laxa.

How does EMILIN1 relate to connective tissue disorders?

EMILIN1 is involved in maintaining the structural integrity of connective tissues, and its dysregulation has been linked to connective tissue disorders such as Marfan syndrome and Ehlers-Danlos syndrome.

What are the potential implications of EMILIN1 in neurological disorders?

EMILIN1 has been studied for its potential role in neurodevelopment and synaptic function, and its dysregulation may have implications for neurological disorders such as autism and schizophrenia.