Recombinant Human EIF4EBP1 protein, His-tagged

• Cat.No.: EIF4EBP1-154H
• Product Overview: Recombinant Human EIF4EBP1(Ser2-Ile118) fused with His tag at C-terminal was expressed in E. coli.

Specification

• Description: This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Lyophilized from a 0.2 µM filtered solution of 20mM Phosphate buffer, 150mM NaCl, pH 7.4.
• Molecular Mass: 14.7 kDa
• Protein length: Ser2-Ile118
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining
• Storage: Stable for at least 6 months from date of receipt under proper storage and handling conditions.
• Concentration: Resuspend the protein to the desired concentration in proper buffer.

Gene Information

• Gene Name: EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 [ Homo sapiens ]
• Official Symbol: EIF4EBP1
• Synonyms: EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1; eukaryotic translation initiation factor 4E-binding protein 1; 4E BP1; PHAS I; phosphorylated heat and acid stable protein regulated by insulin 1; eIF4E-binding protein 1; phosphorylated heat- and acid-stable protein regulated by insulin 1; BP-1; 4EBP1; 4E-BP1; PHAS-I; MGC4316
• Gene ID: 1978
• mRNA Refseq: NM_004095
• Protein Refseq: NP_004086
• MIM: 602223
• UniProt ID: Q13541