EIF4EBP1
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Official Full Name
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 -
Overview
Eukaryotic translation initiation factor 4E-binding protein 1 is a protein that in humans is encoded by the EIF4EBP1 gene. This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. -
Synonyms
EIF4EBP1;eukaryotic translation initiation factor 4E binding protein 1;eukaryotic translation initiation factor 4E-binding protein 1;4E BP1;PHAS I;phosphorylated heat and acid stable protein regulated by insulin 1;eIF4E-binding protein 1;phosphorylated heat- and acid-stable protein regulated by insulin 1;BP-1;4EBP1;4E-BP1;PHAS-I;MGC4316
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- Mouse
- Human Cells
- In Vitro Cell Free System
- His
- Non
- GST
- Flag
- Avi
- Fc
Involved Pathway
EIF4EBP1 involved in several pathways and played different roles in them. We selected most pathways EIF4EBP1 participated on our site, such as AMPK signaling,AMPK signaling pathway,Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF4EBP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Acute myeloid leukemia | RAF1,STAT5A,CEBPA,TCF7L2,PIK3R2,SOS1,MAPK3,PIM1,PIK3CA,FLT3 |
| AMPK signaling | PPARGC1B,LOC729991,INS-IGF2,CPT1A,ELAVL1,CAMKK2,ADRA1B,CPT1B,EEF2,CPT1C |
| BDNF signaling pathway | YBX1,SYN1,IGF2BP1,EEF2,CSNK2A1,BCL2L11,LINGO1,CNR1,FRS3,EIF4E |
| AMPK signaling pathway | SCD,PIK3R1,PIK3R5,CPT1C,PFKFB1,PPP2R1A,FOXO1,FBP1,PPP2R2C,PFKM |
| Cap-dependent Translation Initiation | EIF4H,EIF2S1,EIF4G1,RPL35,EIF3K,EIF4EB,EIF4A1,EIF2B1,EIF1AX,EIF4B |
| Alpha6-Beta4 Integrin Signaling Pathway | CDKN1A,CD151,SMAD3B,DSP,YWHAQ,CLCA1,EGFR,EIF4EB,COL17A1,NTN1A |
| Choline metabolism in cancer | PRKCB,MTOR,PIK3R2,MAPK3,SLC22A2,DGKQ,PRKCA,GRB2,PIP5K1C,RPS6KB2 |
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | EIF4H,EIF2S1A,EIF1AX,EIF4EB,FAUB,EIF4A1,EIF4A2,EIF4E,EIF4B,EIF2S3 |
Protein Function
EIF4EBP1 has several biochemical functions, for example, eukaryotic initiation factor 4E binding,protein binding,protein phosphatase 2A binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF4EBP1 itself. We selected most functions EIF4EBP1 had, and list some proteins which have the same functions with EIF4EBP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | VPS54,HELZ,SMC6,SYNJ2BP,NFATC3,RSPH3,EFNA1,CCDC88A,FCER1G,DST |
| translation repressor activity | CIRBP,IREB2,SAMD4A,EIF4EBP2,PAIP2,PATL2,SAMD4,EIF4EBP3,TRIM71 |
| eukaryotic initiation factor 4E binding | EIF4EBP3L,LARP1,EIF4G1,EIF4EBP2,ANGEL1,HHEX,OTX2,EIF4EBP3,DDX3X,GRA |
| protein phosphatase 2A binding | SMG7,CTTNBP2NL,MASTL,STRN4,BCL2,GRIN3A,STRN,AKT1,TRP53,ARPP19 |
Interacting Protein
EIF4EBP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF4EBP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF4EBP1.
EIF4E;RPTOR;TCF4
EIF4EBP1 Related Signal Pathway
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References
- Wang, ZS; Ma, XH; et al. Understanding the mechanistic roles of 30Kc6 gene in apoptosis and specific productivity in antibody-producing Chinese hamster ovary cells. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 94:1243-1253(2012).
- Bidinosti, M; Martineau, Y; et al. Repair of Isoaspartate Formation Modulates the Interaction of Deamidated 4E-BP2 with mTORC1 in Brain. JOURNAL OF BIOLOGICAL CHEMISTRY 285:19402-19408(2010).
