Recombinant Human EDA2R protein, hIgG/His-tagged

• Cat.No.: EDA2R-132H
• Product Overview: Recombinant Human EDA2R(1-138aa) fused with hIgG/His tag at C-terminal was expressed in Insect cells.

Specification

• Species: Human
• Source: Insect Cells
• Tag: Fc&His
• Protein Length: 1-138 a.a.
• Description: EDA2R also known as Tumor necrosis factor receptor superfamily member 27 isoform 2, is a transmembrane protein in the TNF receptor superfamily. This protein itself is strongly associated with androgenetic alopecia (male hair loss). It is widely expressed, notably in embryonic basal epidermal cells and maturing hair follicles. Even though it does not contain a cytoplasmic death domain, it can associate with Fas and induce EDA-A2 dependent apoptosis.
• Form: Liquid. In Phosphate Buffered Saline (pH 7.4) containing 20% glycerol, 1mM DTT.
• Molecular Mass: 42.5kDa (380aa)
  40-57KDa (SDS-PAGE under reducing conditions.)
• AA Sequence: ADPMDCQENE YWDQWGRCVT CQRCGPGQEL SKDCGYGEGG DAYCTACPPR RYKSSWGHHR CQSCITCAVI NRVQKVNCTA TSNAVCGDCL PRFYRKTRIG GLQDQECIPC TKQTPTSEVQ CAFQLSLVEA DAPTVPPQEA TLEPKSCDKT HTCPPCPAPE LLGGPSVFLF PPKPKDTLMI SRTPEVTCVV VDVSHEDPEV KFNWYVDGVE VHNAKTKPRE EQYNSTYRVV SVLTVLHQDW LNGKEYKCKV SNKALPAPIE KTISKAKGQP REPQVYTLPP SRDELTKNQV SLTCLVKGFY PSDIAVEWES NGQPENNYKT TPPVLDSDGS FFLYSKLTVD KSRWQQGNVF SCSVMHEALH NHYTQKSLSL SPGKHHHHHH
• Endotoxin: < 1.0 EU per 1 microgram of protein (determined by LAL method)
• Purity: > 90% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5mg/ml (determined by Absorbance at 280nm)

Gene Information

• Gene Name: EDA2R ectodysplasin A2 receptor [ Homo sapiens ]
• Official Symbol: EDA2R
• Synonyms: EDA2R; ectodysplasin A2 receptor; tumor necrosis factor receptor superfamily member 27; EDA A2R; EDAA2R; TNFRSF27; XEDAR; EDA-A2 receptor; X-linked ectodysplasin-A2 receptor; tumor necrosis factor receptor superfamily member XEDAR; EDA-A2R
• Gene ID: 60401
• mRNA Refseq: NM_001242310
• Protein Refseq: NP_001229239
• MIM: 300276
• UniProt ID: Q9HAV5
• Chromosome Location: Xq11.1
• Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem
• Function: protein binding; receptor activity; tumor necrosis factor-activated receptor activity