EDA2R
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Official Full Name
ectodysplasin A2 receptor -
Overview
EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that are encoded by the anhidrotic ectodermal dysplasia (EDA) gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. The protein encoded by this gene specifically binds to EDA-A2 isoform. This protein is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains 3 cysteine-rich repeats and a single transmembrane domain but lacks an N-terminal signal peptide. Alternatively spliced transcript variants have been found for this gene. -
Synonyms
EDA2R;ectodysplasin A2 receptor;XEDAR;EDAA2R;EDA-A2R;TNFRSF27;Tumor necrosis factor receptor superfamily member 27;X-linked ectodysplasin-A2 receptor;EDA-A2 receptor;UNQ2448/PRO5727/PRO34080;OTTHUMP00000023448;tumor necrosis factor receptor superfamily member XEDAR;X-linked EDA-A2 Receptor
Recombinant Proteins
- Human
- Cynomolgus
- Chicken
- Rat
- Mouse
- HEK293
- Human Cell
- C-hFc
- Insect Cell
- Mammalian cells
- Wheat Germ
- E.coli
- Mammalian Cell
- In Vitro Cell Free System
- His
- Fc
- His&Fc
- Non
- GST
- His&Fc&Avi
Involved Pathway
EDA2R involved in several pathways and played different roles in them. We selected most pathways EDA2R participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with EDA2R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | LEPA,CSF2RA,CCL20A.3,CCL22,INHBC,PDGFA,IFNA10,CD40LG,PF4V1,EPOR |
Protein Function
EDA2R has several biochemical functions, for example, protein binding,receptor activity,tumor necrosis factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EDA2R itself. We selected most functions EDA2R had, and list some proteins which have the same functions with EDA2R. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor activity | PVRL1B,LDLR,GPA33,GRIA4B,NCR3,MED13,APLNR,XPR1,GUCY1B3,VMN1R49 |
| protein binding | NKAP,CARTPT,KIAA0146,AVPI1,LRRC47,HDAC3,KCNJ9,NCL,BMPR2,CCND1 |
| tumor necrosis factor-activated receptor activity | TNFRSF14,HDR,TNFRSF25,TNFRSF8,NRADD,TNFRSF4,TNFRSF10A,NGFR,TNFRSF1B,Tnfrsf26 |
Interacting Protein
EDA2R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EDA2R here. Most of them are supplied by our site. Hope this information will be useful for your research of EDA2R.
TRAF3;FADD;CASP8;Eda2r;CASP10;TRAF6;C1QB;CEBPE
EDA2R Related Signal Pathway
Resources
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References
- Nuwaihyd, R; Redler, S; et al. Investigation of four novel male androgenetic alopecia susceptibility loci: no association with female pattern hair loss. ARCHIVES OF DERMATOLOGICAL RESEARCH 306:413-418(2014).
- Hudson, NJ; Porto-Neto, LR; et al. Information compression exploits patterns of genome composition to discriminate populations and highlight regions of evolutionary interest. BMC BIOINFORMATICS 15:-(2014).
