Recombinant Human Dual Specificity Phosphatase 18, His-tagged

• Cat.No.: DUSP18-1923H
• Product Overview: Recombinant human DUSP18protein, fused to His-tag at N-terminus, was expressed in E. coli andpurified by using conventional chromatography.

Specification

• Species: Human
• Tag: His
• Description: DUSP18is a member of the dual-specificity phosphatase (DSP) family, which catalyzesdephosphorylation of phosphotyrosine and phosphothreonine residues. DUSP18 isinhibited by iodoarectic acid and is activated by manganese ions.
• Form: Liquid. In 20mMTris-HCl buffer (pH 8.0) containing 1mM DTT, 40% glycerol, 0.1mM PMSF, 1mMEDTA.
• Molecular Weight: 23.6 kDa(212aa) confirmed by MALDI-TOF
• Purity: > 95%by SDS-PAGE
• Concentration: 0.5mg/ml (determined by Bradford assay)
• Sequences of aminoacids: MGSSHHHHHHSSGLVPRGSH MGSHMTAPSC AFPVQFRQPS VSGLSQITKS LYISNGVAAN NKLMLSSNQI TMVINVSVEVVNTLYEDIQYMQVPVADSPNSRLCDFFDPI ADHIHSVEMK QGRTLLHCAA GVSRSAALCL AYLMKYHAMS LLDAHTWTKS CRPIIRPNSGFWEQLIHYEF QLFGKNTVHM VSSPVGMIPD IYEKEVRLMI PL
• Storage: Can bestored at +4°C short term (1-2 weeks). For long term storage, aliquot andstore at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: DUSP18 dual specificityphosphatase 18 [ Homo sapiens ]
• Official Symbol: DUSP18
• Synonyms: DUSP18; dual specificity phosphatase 18;DSP18; DUSP20; LMWDSP20; bK963H5.1; LMW-DSP20; low molecular weight dualspecificity phosphatase 20; EC 3.1.3.16; EC 3.1.3.48
• Gene ID: 150290
• mRNA Refseq: NM_152511
• Protein Refseq: NP_689724
• MIM: 611446
• UniProt ID: Q8NEJ0
• Chromosome Location: 22q12.1
• Function: MAP kinase tyrosine/serine/threoninephosphatase activity; hydrolase activity; protein tyrosine phosphataseactivity; protein tyrosine/serine/threonine phosphatase activity