Recombinant Human DMPK, GST-tagged, Active

• Cat.No.: DMPK-295H
• Product Overview: Recombinant full-length human DMPK was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW=105 kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: DMPK (or Myotonic Dystrophy Protein Kinase) is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. DMPK protein has a leucine-rich domain at the N-terminus, a serine/threonine kinase domain in the middle, and a hydrophobic region at the C-terminus. The N-terminus of DMPK plays an important role in DMPK kinase activity, and the C-terminus of DMPK determines the intracellular localization of the protein. Myotonic dystrophy type 1 is an autosomal dominant disease caused by a trinucleotide repeat-expansion, cytosine-thymine-guanine (CTG)n, in the 3" untranslated region of DMPK.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: DMPK dystrophia myotonica-protein kinase [ Homo sapiens ]
• Synonyms: DMPK; dystrophia myotonica-protein kinase; DM; DM1; DMK; MDPK; DM1PK; MT-PK; DM protein kinase; myotonic dystrophy protein kinase; thymopoietin homolog; myotonin protein kinase A; myotonic dystrophy associated protein kinase; EC 2.7.11.1
• Gene ID: 1760
• mRNA Refseq: NM_001081560
• Protein Refseq: NP_001075029
• MIM: 605377
• UniProt ID: Q09013
• Chromosome Location: 19q13.3
• Function: ATP binding; magnesium ion binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity