DMPK
-
Official Full Name
Dystrophia Myotonica-Protein Kinase -
Overview
The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-37 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. -
Synonyms
DMPK;dystrophia myotonica-protein kinase;DM;DM1;DMK;MDPK;DM1PK;MT-PK;myotonin-protein kinase;DM-kinase;DM protein kinase;thymopoietin homolog;myotonin protein kinase A;myotonic dystrophy protein kinase;myotonic dystrophy associated protein kinase;EC=2.7.11.1;DM1 protein kinase
Recombinant Proteins
- Rhesus macaque
- Human
- Rat
- Mouse
- Mus musculus
- Mammalian Cells
- Insect Cells
- Wheat Germ
- Sf9 Cells
- E.coli
- HEK293
- In Vitro Cell Free System
- His
- Non
- GST
- His&T7
- Avi&Fc&His
- DDK&Myc
Involved Pathway
DMPK involved in several pathways and played different roles in them. We selected most pathways DMPK participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DMPK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
DMPK has several biochemical functions, for example, ATP binding,heat shock protein binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DMPK itself. We selected most functions DMPK had, and list some proteins which have the same functions with DMPK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | POMP,EGLN1,HIST1H2BI,FLAD1,PPP2R5D,UNKL,SCNN1D,RNF32,BBS4,CSF1 |
| ATP binding | GART,TAP1,CASK,FARS2,PL10,PAPOLG,FPGS,PFKL,DAK,IDH3G |
| heat shock protein binding | BAX,LIMK1,TOMM34,PDXP,DNAJC7,DNAJA3A,APAF1,PARK2,DNAJA2L,LMAN2 |
| metal ion binding | GNS,GM757,ZFP287,ZNF615,PPAT,ZBTB41,ZBED1,PDE6B,KALRN,PAK3 |
| protein serine/threonine kinase activity | CDK5,DYRK2,KALRN,GRK1A,RPS6KA5,MAP3K9,LIMK1,MASTL,ACVR1L,CDC42BPA |
Interacting Protein
DMPK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DMPK here. Most of them are supplied by our site. Hope this information will be useful for your research of DMPK.
PPP1R12A;PLN;HSP90AB1;GABARAP;TK1;ANXA7;RPS10;ATXN1;ATN1;GEMIN4;PIN1;SMN1;purR2;gntT2;UBQLN4
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