Recombinant Human DIS3 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: DIS3-6219H
• Product Overview: DIS3 MS Standard C13 and N15-labeled recombinant protein (NP_055768) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: DIS3 (DIS3 Homolog, Exosome Endoribonuclease And 3'-5' Exoribonuclease) is a Protein Coding gene. Diseases associated with DIS3 include Perlman Syndrome and Axenfeld-Rieger Syndrome, Type 2. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and ATP/ITP metabolism. Gene Ontology (GO) annotations related to this gene include RNA binding and endonuclease activity. An important paralog of this gene is DIS3L.
• Molecular Mass: 109.1 kDa
• AA Sequence: MLKSKTFLKKTRAGGVMKIVREHYLRDDIGCGAPGCAACGGAHEGPALEPQPQDPASSVCPQPHYLLPDTNVLLHQIDVLEDPAIRNVIVLQTVLQEVRNRSAPVYKRIRDVTNNQEKHFYTFTNEHHRETYVEQEQGENANDRNDRAIRVAAKWYNEHLKKMSADNQLQVIFITNDRRNKEKAIEEGIPAFTCEEYVKSLTANPELIDRLACLSEEGNEIESGKIIFSEHLPLSKLQQGIKSGTYLQGTFRASRENYLEATVWIHGDNEENKEIILQGLKHLNRAVHEDIVAVELLPKSQWVAPSSVVLHDEGQNEEDVEKEEERERMLKTAVSEKMLKPTGRVVGIIKRNWRPYCGMLSKSDIKESRRHLFTPADKRIPRIRIETRQASTLEGRRIIVAIDGWPRNSRYPNGHFVRNLGDVGEKETETEVLLLEHDVPHQPFSQAVLSFLPKMPWSITEKDMKNREDLRHLCICSVDPPGCTDIDDALHCRELENGNLEVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKRIDMVPELLSSNLCSLKCDVDRLAFSCIWEMNHNAEILKTKFTKSVINSKASLTYAEAQLRIDSANMNDDITTSLRGLNKLAKILKKRRIEKGALTLSSPEVRFHMDSETHDPIDLQTKELRETNSMVEEFMLLANISVAKKIHEEFSEHALLRKHPAPPPSNYEILVKAARSRNLEIKTDTAKSLAESLDQAESPTFPYLNTLLRILATRCMMQAVYFCSGMDNDFHHYGLASPIYTHFTSPIRRYADVIVHRLLAVAIGADCTYPELTDKHKLADICKNLNFRHKMAQYAQRASVAFHTQLFFKSKGIVSEEAYILFVRKNAIVVLIPKYGLEGTVFFEEKDKPNPQLIYDDEIPSLKIEDTVFHVFDKVKVKIMLDSSNLQHQKIRMSLVEPQIPGISIPTDTSNMDLNGPKKKKMKLGKTRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: DIS3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease [ Homo sapiens (human) ]
• Official Symbol: DIS3
• Synonyms: DIS3; DIS3 mitotic control homolog (S. cerevisiae); KIAA1008; exosome complex exonuclease RRP44; dis3p; EXOSC11; exosome component 11; RRP44; 2810028N01Rik; protein DIS3 homolog; ribosomal RNA-processing protein 44; mitotic control protein dis3 homolog; bA555G22.1; RP11-342J4.3; FLJ10484; MGC33035; DKFZp667L1817
• Gene ID: 22894
• mRNA Refseq: NM_014953
• Protein Refseq: NP_055768
• MIM: 607533
• UniProt ID: Q9Y2L1