Recombinant Human DHCR24 protein, MYC/DDK-tagged

• Cat.No.: DHCR24-105H
• Product Overview: Recombinant Human DHCR24 fused with MYC/DDK tag at C-terminal was expressed in HEK293.

Specification

• Description: This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 57.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Notes: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: DHCR24 24-dehydrocholesterol reductase [ Homo sapiens ]
• Official Symbol: DHCR24
• Synonyms: DHCR24; 24-dehydrocholesterol reductase; delta(24)-sterol reductase; KIAA0018; seladin 1; diminuto/dwarf1 homolog; selective AD indicator 1; desmosterol-to-cholesterol enzyme; 3 beta-hydroxysterol delta 24-reductase; 3-beta-hydroxysterol delta-24-reductase; DCE; SELADIN1; Nbla03646; seladin-1
• Gene ID: 1718
• mRNA Refseq: NM_014762
• Protein Refseq: NP_055577
• MIM: 606418
• UniProt ID: Q15392