DHCR24
-
Official Full Name
24-dehydrocholesterol reductase -
Overview
This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq, Jul 2008] -
Synonyms
DHCR24;24-dehydrocholesterol reductase;DCE;SELADIN1;Nbla03646;seladin-1;delta(24)-sterol reductase;seladin 1;diminuto/dwarf1 homolog;selective AD indicator 1;desmosterol-to-cholesterol enzyme;3 beta-hydroxysterol delta 24-reductase;3-beta-hydroxysterol delta-24-reductase
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Cynomolgus
- Mouse
- E.coli
- HEK293
- Wheat Germ
- Mammalian Cell
- Mammalian cells
- HEK293T
- In Vitro Cell Free System
- GST
- Myc&DDK
- His
- Non
- His&Fc&Avi
- Flag
Involved Pathway
DHCR24 involved in several pathways and played different roles in them. We selected most pathways DHCR24 participated on our site, such as Cholesterol biosynthesis,Metabolic pathways,Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with DHCR24 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Tryptophan metabolism | AANAT2,CAT,CYP2F1,ALDH2.2,ALDH2,TDO2A,GCDHB,OGDHL,OGDHA,CYP1A |
| Metabolism | GNG13B,ACOT6,GLS2B,FABP1B.1,COQ7,CETP,RHAG,CYP26A1,MED6,ACSF3 |
| cholesterol biosynthesis I | DHCR7,LBR,EBP |
| cholesterol biosynthesis II (via 24,25-dihydrolanosterol) | EBP,LBR |
| Metabolism of lipids and lipoproteins | PPM1LA,PPARGC1B,NEU4,FABP12,APOF,CPNE1,FAAH2A,FIG4,PEMT,GLTP |
| Steroid biosynthesis | FDFT1,SQLEA,CEL.1,NSDHL,CYP51,DHCR7,CYP2R1,HSD17B7,LSS,SOAT2 |
| Metabolic pathways | GUSB,CYP3A65,BDH2,LIPT1,PTGS1,PTGDSB,APIP,B3GALT4,POLR2I,UGT1AB |
| Cholesterol biosynthesis | LBR,ARV1,CYP51A1,EBP,SREBF2,DHCR7,PMVK |
Protein Function
DHCR24 has several biochemical functions, for example, delta24(24-1) sterol reductase activity,delta24-sterol reductase activity,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DHCR24 itself. We selected most functions DHCR24 had, and list some proteins which have the same functions with DHCR24. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peptide antigen binding | MHC1ZHA,HLA-DRB4,HLA-DQA1,CD209,MHC1UIA,H2-AA,MHC1UBA,HLA-DPA1,HLA-A,HLA-G |
| enzyme binding | Ar,PLAUR,EIF4E,LDB1,SCARB2,HDAC10,HDAC2,YWHAB,TSPAN14,UGT1A6 |
| oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor | SRD5A3,TM7SF2,LBR,BDH2 |
| oxidoreductase activity, acting on CH-OH group of donors | AOX1,AOX3,GULO,AOX3L1,AGPS,XDH,AOX4 |
| flavin adenine dinucleotide binding | DPYD,SQLE,FMO1,NOS2,DLD,ACAD11,SDHA,AOX3,ACOX1,CHDH |
Interacting Protein
DHCR24 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DHCR24 here. Most of them are supplied by our site. Hope this information will be useful for your research of DHCR24.
env;15-deoxy-delta(12,14;ssrna_ug;IKBKB;Atp2a2;GBA;Nedd1;Fbl;SNCA;Jup;CKAP5;Ufl1;q99ib8-pro_0000045602;SLC38A1
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