Recombinant Human DEFA5 Protein (Glu20-Arg94), His tagged

• Cat.No.: DEFA5-1943H
• Product Overview: Recombinant human DEFA5 (Glu20-Arg94) fused with His tag was expressed in E. coli.

Specification

• Description: Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 10.15 kDa
• Protein length: Glu20-Arg94
• Purity: >90% as determined by SDS-PAGE
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: DEFA5 defensin, alpha 5, Paneth cell-specific [ Homo sapiens (human) ]
• Official Symbol: DEFA5
• Synonyms: DEFA5; defensin, alpha 5, Paneth cell-specific; DEF5; defensin-5; HD 5; defensin 5; defensin, alpha 5, preproprotein; HD-5; MGC129728
• Gene ID: 1670
• mRNA Refseq: NM_021010
• Protein Refseq: NP_066290
• MIM: 600472
• UniProt ID: Q01523

Reviews

08/16/2019

The product's established reputation in the scientific community provided assurance of its reliability.

07/07/2019

The product's innovative features hinted at its potential for advancing our research in uncharted territories.

12/20/2016

We were excited about the product's role in driving future discoveries in our field of study.

Q&As

Is DEFA5 linked to any diseases?

Altered DEFA5 expression has been associated with various gastrointestinal disorders, including inflammatory bowel diseases (IBD).

Are there specific diseases where DEFA5 is implicated?

DEFA5 has been implicated in conditions such as inflammatory bowel diseases (IBD) and other gastrointestinal disorders.

What is the significance of DEFA5?

DEFA5, known as Defensin Alpha 5, is a crucial member of the defensin family, functioning as an antimicrobial peptide.

What role does DEFA5 play in innate immunity?

DEFA5 contributes to innate immunity by directly targeting and inhibiting the growth of pathogenic microorganisms in the gut.

How does DEFA5 function in host defense?

DEFA5 acts as an antimicrobial peptide, defending the gut against bacterial infections and helping maintain a balanced gut microbiota.

Can DEFA5 be a potential therapeutic target?

DEFA5 is being investigated as a potential therapeutic target for conditions involving gut infections and imbalances in the gut microbiota.

What is the primary tissue of expression for DEFA5?

DEFA5 is primarily expressed in Paneth cells located in the small intestine, contributing to innate immune defense in the gut.