Recombinant Human DEFA5 Protein, MYC/DDK-tagged

• Cat.No.: DEFA5-450H
• Product Overview: Recombinant Human DEFA5 fused with MYC/DDK tag at C-terminal was expressed in HEK293.

Specification

• Description: Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum.
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 8.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: DEFA5 defensin, alpha 5, Paneth cell-specific [ Homo sapiens ]
• Official Symbol: DEFA5
• Synonyms: DEFA5; defensin, alpha 5, Paneth cell-specific; DEF5; defensin-5; HD 5; defensin 5; defensin, alpha 5, preproprotein; HD-5; MGC129728
• Gene ID: 1670
• mRNA Refseq: NM_021010
• Protein Refseq: NP_066290
• MIM: 600472
• UniProt ID: Q01523

Reviews

08/16/2019

The product's established reputation in the scientific community provided assurance of its reliability.

07/07/2019

The product's innovative features hinted at its potential for advancing our research in uncharted territories.

12/20/2016

We were excited about the product's role in driving future discoveries in our field of study.

Q&As

Is DEFA5 linked to any diseases?

Altered DEFA5 expression has been associated with various gastrointestinal disorders, including inflammatory bowel diseases (IBD).

Are there specific diseases where DEFA5 is implicated?

DEFA5 has been implicated in conditions such as inflammatory bowel diseases (IBD) and other gastrointestinal disorders.

What is the significance of DEFA5?

DEFA5, known as Defensin Alpha 5, is a crucial member of the defensin family, functioning as an antimicrobial peptide.

What role does DEFA5 play in innate immunity?

DEFA5 contributes to innate immunity by directly targeting and inhibiting the growth of pathogenic microorganisms in the gut.

How does DEFA5 function in host defense?

DEFA5 acts as an antimicrobial peptide, defending the gut against bacterial infections and helping maintain a balanced gut microbiota.

Can DEFA5 be a potential therapeutic target?

DEFA5 is being investigated as a potential therapeutic target for conditions involving gut infections and imbalances in the gut microbiota.

What is the primary tissue of expression for DEFA5?

DEFA5 is primarily expressed in Paneth cells located in the small intestine, contributing to innate immune defense in the gut.