DEFA5
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Official Full Name
defensin, alpha 5, Paneth cell-specific -
Overview
Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum. -
Synonyms
DEFA5;defensin, alpha 5, Paneth cell-specific;DEF5;defensin-5;HD 5;defensin 5;defensin, alpha 5, preproprotein;HD-5;MGC129728
Recombinant Proteins
- Human
- Mouse
- E.coli
- Wheat Germ
- E.Coli/Yeast
- HEK293
- In Vitro Cell Free System
- Mammalian Cells
- GST
- His
- DDK
- Myc
- Non
- Flag
- Avi
- Fc
Involved Pathway
DEFA5 involved in several pathways and played different roles in them. We selected most pathways DEFA5 participated on our site, such as Alpha-defensins,Defensins,Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with DEFA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Immune System | POLR3H,LILRB4,PANX1,SIGLEC5,IRAK3,CYLD,DEFB119,ACTR1B,CD200R4,GBP6 |
| Alpha-defensins | DEFA6,DEFA3,DEFA1,ART1 |
| Defensins | DEFB103A,DEFB4A,DEFB121,DEFB106A,DEFB125,DEFB104A,DEFA1,DEFA6,CCR6,DEFA3 |
| Innate Immune System | LAT2,RNF135,BTR09,PANX1A,TAX1BP1,CTS7,PANX1,MGC174857,KIR2DS2,DEFB4B |
Protein Function
DEFA5 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by DEFA5 itself. We selected most functions DEFA5 had, and list some proteins which have the same functions with DEFA5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
DEFA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DEFA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of DEFA5.
DTX1
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