DEFA5
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Official Full Name
defensin, alpha 5, Paneth cell-specific
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Overview
Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum. -
Synonyms
DEFA5; defensin, alpha 5, Paneth cell-specific; DEF5; defensin-5; HD 5; defensin 5; defensin, alpha 5, preproprotein; HD-5; MGC129728;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- Fc
- Avi
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
DEFA5 involved in several pathways and played different roles in them. We selected most pathways DEFA5 participated on our site, such as Alpha-defensins, Defensins, Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with DEFA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alpha-defensins | ART1;DEFA6;DEFA5;DEFA3;DEFA1 |
| Defensins | DEFA5;DEFB1;DEFB4B;DEFA3;DEFB104A;DEFB119;DEFB106A;ART1;DEFB121 |
| Immune System | WIPF3;PPIAL4A;ASB4;ASB14;RNF25;SIGLEC7;WWP1;TNFSF13B;WSB1 |
| Innate Immune System | PLD4;CHST13;DEFA6;AGER;CYLD;TXNIPA;MASP2;CASP4;CD300E |
DEFA5 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by DEFA5 itself. We selected most functions DEFA5 had, and list some proteins which have the same functions with DEFA5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
DEFA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DEFA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of DEFA5.
DTX1
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewThe product's established reputation in the scientific community provided assurance of its reliability.
The product's innovative features hinted at its potential for advancing our research in uncharted territories.
We were excited about the product's role in driving future discoveries in our field of study.
Q&As (7)
Ask a questionAltered DEFA5 expression has been associated with various gastrointestinal disorders, including inflammatory bowel diseases (IBD).
DEFA5 has been implicated in conditions such as inflammatory bowel diseases (IBD) and other gastrointestinal disorders.
DEFA5, known as Defensin Alpha 5, is a crucial member of the defensin family, functioning as an antimicrobial peptide.
DEFA5 contributes to innate immunity by directly targeting and inhibiting the growth of pathogenic microorganisms in the gut.
DEFA5 acts as an antimicrobial peptide, defending the gut against bacterial infections and helping maintain a balanced gut microbiota.
DEFA5 is being investigated as a potential therapeutic target for conditions involving gut infections and imbalances in the gut microbiota.
DEFA5 is primarily expressed in Paneth cells located in the small intestine, contributing to innate immune defense in the gut.
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