Recombinant Human DEDD, His-tagged

• Cat.No.: DEDD-7245H
• Product Overview: Recombinant human DEDD protein, fused to His-tag at N-terminus, was expressed in E.coli.

Specification

• description: Death effector domain-containing protein, also known as DEDD, is a cytoplasmic protein. It translocates to the nucleus during CD95-mediated apoptosis, where it localizes to nucleoli-like structures, activates caspase-6 and specifically inhibits RNA polymerase I-dependent transcription. The cell death activity of DEDD relates to its nuclear localization. DEDD is widely expressed in a variety of tissues, with highest levels in the testis. Overexpression of this gene was shown to induce weak apoptosis.
• source: E. coli
• species: Human
• tag: His
• form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol
• molecular mass: 38.9 kDa (338aa)
• protein length: 1-318aa
• aa sequence: MGSSHHHHHH SSGLVPRGSH MAGLKRRASQ VWPEEHGEQE HGLYSLHRMF DIVGTHLTHR DVRVLSFLFV DVIDDHERGL IRNGRDFLLALERQGRCDES NFRQVLQLLR IITRHDLLPY VTLKRRRAVC PDLVDKYLEE TSIRYVTPRA LSDPEPRPPQ PSKTVPPHYP VVCCPTSGPQ MCSKRPARGR ATLGSQRKRR KSVTPDPKEK QTCDIRLRVR AEYCQHETAL QGNVFSNKQD PLERQFERFN QANTILKSRD LGSIICDIKFSELTYLDAFW RDYINGSLLE ALKGVFITDS LKQAVGHEAI KLLVNVDEED YELGRQKLLR NLMLQALP
• purity: >85% by SDS - PAGE
• applications: SDS-PAGE
• storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• concentration: 0.5 mg/ml

Gene Information

• gene name: DEDD death effector domain containing [ Homo sapiens ]
• official symbol: DEDD
• synonyms: DEDD; death effector domain containing; death effector domain-containing protein; CASP8IP1; DEDD1; DEFT; FLDED1; KE05; DEDPro1; FLDED-1; death effector domain-containing testicular molecule
• Gene ID: 9191
• mrna refseq: NM_001039711
• protein refseq: NP_001034800
• mim: 606841
• uniprot id: O75618
• chromosome location: 1q23.1
• function: DNA binding; protein binding