Recombinant Human Death-Associated Protein Kinase 2, His-tagged

• Cat.No.: DAPK2-675H
• Product Overview: Recombinant humanfull length DAPK2 with His tag. No special measures were taken to activatethis kinase.

Specification

• Species: Human
• Source: Insect Cells
• Tag: His
• Description: Death-associatedprotein kinase 2 is an enzyme that in humans is encoded by the DAPK2 gene.This gene encodes a protein that belongs to the serine/threonine proteinkinase family. This protein contains a N-terminal protein kinase domainfollowed by a conserved calmodulin-binding domain with significant similarityto that of death-associated protein kinase 1 (DAPK1), a positive regulator ofprogrammed cell death. Overexpression of this gene was shown to induce cellapoptosis. It uses multiple polyadenylation sites. The DAPK2 mRNA may undergoalternative splicing to produce a DAPK3-like encoding transcript.
• Form: Liquid in 50 mMTris, pH 7.5 + 300 mM NaCl + 0.5 mM EDTA + 0.05% Brij-35 + 2 Mm DTT + 50%glycerol.
• Molecular Weight: 47.9 kDa
• Concentration: 0.28 mg/ml
• Purity: ≥ 90% as determinedby SDS-PAGE analysis.
• Storage: Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: DAPK2
• Full Length: Full L.

Gene Information

• Gene Name: DAPK2 death-associated proteinkinase 2 [ Homo sapiens ]
• Synonyms: DAPK2;death-associated protein kinase 2; DRP1; DRP-1; MGC119312; death-associatedprotein kinase 2; DAP kinase 2; OTTHUMP00000163874; DAP-kinase-related protein1 beta isoform; DAP-kinase-related protein 1; EC 2.7.11.1; EC 2.7.11
• Gene ID: 23604
• mRNA Refseq: NM_014326
• Protein Refseq: NP_055141
• UniProt ID: Q9UIK4
• Chromosome Location: 15q22.31
• Pathway: Apoptosis; Bladdercancer; Pathways in cancer; Regulation of Apoptosis; Role of DCC inregulating apoptosis
• Function: ATP binding;calmodulin binding; calmodulin-dependent protein kinase activity; identicalprotein binding; nucleotide binding; protein serine/threonine kinase activity