Recombinant Human DAPK2, GST-tagged, Active

• Cat.No.: DAPK2-290H
• Product Overview: Recombinant human full-length DAPK2 was expressed by baculovirus inSf9 insect cellsusing a N-terminal GST tag. MW= 67kDa.

Specification

• Cat. No.: DAPK2-290H
• Description: DAPK2 or death-associated protein kinase 2 belongs to a family of proapoptotic Ca /calmodulin-regulated serine/threonine kinases. Overexpression of DAPK2 induces cell apoptosis. DAPK2 has been shown to be a novel Sp1-dependent target gene for E2F1 and Krüppel-like factor 6 (KLF6) in cell death response. Both E2F1 and KLF6 strongly activate the DAPK2 promoter. DAPK2 plays a role in granulopoiesis where it is highly expressed. β-catenin can block anoikis of malignant kidney and intestinal epithelial cells and promote their anchorage-independent growth by down-regulating DAPK2. β-catenin-induced down-regulation of DAPK2 requires the presence of the transcription factor TCF-4.
• Source: Sf9 insect cellsusing baculovirus.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70^oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: DAPK2 death-associated protein kinase 2 [ Homo sapiens ]
• Synonyms: DAPK2; death-associated protein kinase 2; DRP1; DRP-1; MGC119312; DAP kinase 2; OTTHUMP00000163874; DAP-kinase-related protein 1; EC 2.7.11.1
• Gene ID: 23604
• mRNA Refseq: NM_014326
• Protein Refseq: NP_055141
• UniProt ID: Q9UIK4
• Chromosome Location: 15q22.31
• Pathway: Bladder cancer; Pathways in cancer
• Function: ATP binding; calmodulin binding; nucleotide binding ; protein serine/threonine kinase activity transferase activity