Recombinant Human CR1 therapeutic protein(Mirococept)

• Cat.No.: CR1-P016H
• Product Overview: Recombinant Human complement receptor 1 therapeutic protein is a complement inhibitor currently under development for treatment of rheumatoid arthritis and I/RI. It consists of the first three short consensus domains of human complement receptor 1, manufactured in recombinant bacteria and modified with a membrane-targeting amphiphilic peptide based on the naturally occurring membrane-bound myristoyl-electrostatic switch peptide.

Specification

• Description: This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized.
• Species: Human
• Endotoxin: < 1.0 EU per μg of the protein
• Purity: >98%
• Tag: Non
• Alias: CR1; CD35; KN; C3BR; C4BR; Mirococept

Gene Information

• Gene Name: CR1 complement component (3b/4b) receptor 1 (Knops blood group) [ Homo sapiens ]
• Official Symbol: CR1
• Synonyms: CR1; complement component (3b/4b) receptor 1 (Knops blood group); complement component (3b/4b) receptor 1, including Knops blood group system; complement receptor type 1; CD35; KN; CD35 antigen; C3b/C4b receptor; C3-binding protein; Knops blood group antigen; complement component receptor 1; C3BR; C4BR
• Gene ID: 1378
• mRNA Refseq: NM_000573
• Protein Refseq: NP_000564
• MIM: 120620
• UniProt ID: P17927
• Chromosome Location: 1q32
• Pathway: Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Complement cascade, organism-specific biosystem; Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem; Immune System, organism-specific biosystem
• Function: complement component C3b binding; complement component C3b receptor activity; complement component C4b binding; complement component C4b receptor activity; receptor activity

Reviews

11/16/2021

The CR1 protein product received was as advertised, top quality and good value for money.

03/14/2021

The staff actively communicated with me and solved many technical problems.

10/19/2020

The technician gave me a thorough introduction to the CR1 protein so that I could understand its biochemical properties.

Q&As

What diseases is CR1 involved in?

CR1 is involved in the study of systemic lupus erythematosus and Alzheimer's disease.

Where is CR1 primarily expressed?

CR1 is predominantly expressed on peripheral blood cell membranes.

What biological processes is CR1 involved in?

CR1 plays a role in Aβ clearance, neuroinflammation, and taurine lesions.

What are the components of CR1?

CR1 consists of four major structural domains: 41aa signaling peptide, extracellular structural domain, 25aa transmembrane structural domain, and 43aa cytoplasmic structural domain.