Recombinant Human COL1A1 / Collagen, Type I, Alpha 1 protein

• Cat.No.: COL1A1-1207H
• Product Overview: Recombinant Human COL1A1 active fragments was metabolized and expressed by Pichia pastoris using synthetic biology technology. Sponge like solids are obtained by solid-liquid separation, ultrafiltration, chromatography, freeze-drying, and other processes from the fermentation broth. It has the characteristics of high purity, high activity, high stability, high homology and low immunogenicity.

Specification

• Description: Collagen, type I,alpha 1, also known as COL1A1, is a human gene that encodes the majorcomponent of type I collagen, the fibrillar collagen found in most connectivetissues, including cartilage. Collagen is a protein that strengthens andsupports many tissues in the body, including cartilage, bone, tendon, skin and thewhite part of the eye (sclera). The COL1A1 gene produces a component of typeI collagen, called the pro-alpha1(I) chain. This chain combines with anotherpro-alpha1(I) chain and also with a pro-alpha2(I) chain (produced by theCOL1A2 gene) to make a molecule of type I procollagen. These triple-stranded,rope-like procollagen molecules must be processed by enzymes outside thecell. Once these molecules are processed, they arrange themselves into long,thin fibrils that cross-link to one another in the spaces around cells. Thecross-links result in the formation of very strong mature type I collagenfibers.
• Source: Pichia pastoris
• Species: Human
• Tag: Non
• Form: Sterile Filtered White lyophilized (freeze-dried) powder.
• Purity: >90% as determined by SDS-PAGE.
• Applications: Can be used for moisturizing, tightening, wrinkle removing, and anti-aging products; Suitable dosage forms include toner, gel, essence, lotion, cream and facial mask.
• Usage: Recommended Dosage: 0.01%~1%
• Storage: Sealed, stored at 0~4℃, recommended for long-term storage at -20 ℃~-15 ℃.
• Reconstitution: Reconstitute in sterile water for a stock solution. For cosmetic addition, it is recommended to add in the final stage of cosmetic production, adding temperature does not exceed 40 °C, mixed evenly.

Gene Information

• Gene Name: COL1A1 collagen, type I, alpha 1 [ Homo sapiens ]
• Official Symbol: COL1A1
• Synonyms: COL1A1; collagen, type I, alpha 1; collagen alpha-1(I) chain; OI4; alpha-1 type I collagen; pro-alpha-1 collagen type 1; collagen alpha 1 chain type I; collagen alpha-1(I) chain preproprotein; collagen of skin, tendon and bone, alpha-1 chain
• Gene ID: 1277
• mRNA Refseq: NM_000088
• Protein Refseq: NP_000079
• UniProt ID: P02452