Recombinant Human CLEC6A Protein, Thr46-Leu209, N-6×His tagged

• Cat.No.: CLEC6A-13H
• Product Overview: Recombinant Human CLEC6A Protein, Thr46-Leu209, with an N-terminal 6-His tag was expressed in Mouse myeloma cell line.

Specification

• Description: The protein encoded by this gene is a type II membrane receptor with an extracellular C-type lectin-like domain fold. The extracellular portion binds structures with a high mannose content and has been shown to recognize several pathogens, including C. elegans, S. cerevisiae, M. tuberculosis, C. neoformans, and house dust mite. When stimulated, the encoded protein initiates signalling through the CARD9-Bcl10-Malt1 pathway, leading to the induction of cytokines. Two transcript variants encoding different isoforms have been found for this gene.
• Source: Mouse myeloma cell line
• Species: Human
• Tag: His
• Protein length: Thr46-Leu209
• Molecular Mass: Predicted Molecular Mass: 19.7 kDa
  SDS-PAGE: 20-24 kDa, reducing conditions
• Endotoxin: < 1.0 EU/μg of the protein by the LAL method.
• Purity: > 90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  12 months from date of receipt, -20 to -70 centigrade as supplied.
  1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
  3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution in PBS.
• Shipping: The product is shipped at ambient temperature.
• Reconstitution: Reconstitute at 100 μg/mL in sterile PBS.
• References: 1. Kanazawa, N. (2007) J. Dermatol. Sci. 45:77.
  2. Kanazawa, N. et al. (2004) Immunobiology 209:179.
  3. Flornes, L.M. et al. (2004) Immunogenetics 56:506.

Gene Information

• Gene Name: CLEC6A C-type lectin domain family 6, member A [ Homo sapiens (human) ]
• Official Symbol: CLEC6A
• Synonyms: CLEC6A; C-type lectin domain family 6, member A; C type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 10 , CLECSF10; C-type lectin domain family 6 member A; dectin 2; dectin-2; DC-associated C-type lectin 2; C-type lectin superfamily member 10; dendritic cell-associated C-type lectin 2; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 10; CLEC4N; CLECSF10
• Gene ID: 93978
• mRNA Refseq: NM_001007033
• Protein Refseq: NP_001007034
• MIM: 613579
• UniProt ID: Q6EIG7