Recombinant Human CHRNA3, His-tagged
Cat.No. : | CHRNA3-86H |
Product Overview : | Recombinant human CHRNA3 protein, fused to His-tag at N-terminus, was expressed in E.coli. |
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Species : | Human |
Source : | E.coli |
Tag : | His |
Description : | CHRNA3 also known as neuronal acetylcholine receptor subunit alpha-3 isoform 1 is a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. CHRNA3 is a ligand-gated ion channel that likely plays a role in neurotransmission. CHRNA3 have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described. |
Form : | Liquid. In 20mM Tris-HCl buffer(pH8.0) containing 10% glycerol |
Molecular Mass : | 27kDa (232aa) |
AA Sequence : | MGSSHHHHHH SSGLVPRGSH MGSSEAEHRL FERLFEDYNE IIRPVANVSD PVIIHFEVSM SQLVKVDEVN QIMETNLWLK QIWNDYKLKW NPSDYGGAEF MRVPAQKIWK PDIVLYNNAV GDFQVDDKTK ALLKYTGEVT WIPPAIFKSS CKIDVTYFPF DYQNCTMKFG SWSYDKAKID LVLIGSSMNL KDYWESGEWA IIKAPGYKHD IKYNCCEEIY PDITYSLYIR RL |
Purity : | >80% by SDS - PAGE |
Storage : | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles. |
Concentration : | 1mg/ml (determined by assay) |
Gene Name | CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) [ Homo sapiens ] |
Official Symbol | CHRNA3 |
Synonyms | CHRNA3; cholinergic receptor, nicotinic, alpha 3 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 3; neuronal acetylcholine receptor subunit alpha-3; acetylcholine receptor; nicotinic; alpha 3 (neuronal); neuronal nicotinic acetylcholine receptor, alpha3 subunit; LNCR2; PAOD2; NACHRA3; MGC104879; |
Gene ID | 1136 |
mRNA Refseq | NM_000743 |
Protein Refseq | NP_000734 |
MIM | 118503 |
UniProt ID | P32297 |
Chromosome Location | 15q24 |
Pathway | Acetylcholine Binding And Downstream Events, organism-specific biosystem; Activation of Nicotinic Acetylcholine Receptors, organism-specific biosystem; Cholinergic synapse, organism-specific biosystem; Highly calcium permeable nicotinic acetylcholine receptors, organism-specific biosystem; Highly calcium permeable postsynaptic nicotinic acetylcholine receptors, organism-specific biosystem; Highly sodium permeable acetylcholine nicotinic receptors, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; |
Function | acetylcholine binding; acetylcholine receptor activity; acetylcholine-activated cation-selective channel activity; acetylcholine-activated cation-selective channel activity; extracellular ligand-gated ion channel activity; ligand-gated ion channel activity; receptor activity; |
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Not For Human Consumption!
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