CHRNA3
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Official Full Name
cholinergic receptor, nicotinic, alpha 3 -
Overview
This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described. -
Synonyms
CHRNA3;cholinergic receptor, nicotinic, alpha 3;cholinergic receptor, nicotinic, alpha polypeptide 3;NACHRA3;LNCR2;PAOD2;MGC104879;neuronal acetylcholine receptor subunit alpha-3;neuronal nicotinic acetylcholine receptor, alpha3 subunit;OTTHUMP00000185024;OTTHUMP00000185025
Recombinant Proteins
- Human
- Chicken
- Rat
- E.coli
- Wheat Germ
- Mammalian Cell
- Yeast
- Insect Cell
- In Vitro Cell Free System
- E.coli expression system
- GST
- His
- His&Myc&SUMO
- Non
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CHRNA3-11211H | Recombinant Human CHRNA3, GST-tagged | E.coli | Human | GST | 32-238a.a. | |
| CHRNA3-1280H | Recombinant Human CHRNA3 Protein, GST-Tagged | Wheat Germ | Human | GST |
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| CHRNA3-5986C | Recombinant Chicken CHRNA3 | Mammalian Cell | Chicken | His |
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| CHRNA3-86H | Recombinant Human CHRNA3, His-tagged | E.coli | Human | His |
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| CHRNA3-1723H | Recombinant Human CHRNA3 Protein (Ser32-Leu240), N-His tagged | E.coli | Human | His | Ser32-Leu240 |
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| CHRNA3-2691H | Recombinant Human CHRNA3 Protein (32-240 aa), His-tagged | Yeast | Human | His | 32-240 aa |
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| CHRNA3-2697H | Recombinant Human CHRNA3 protein, His-SUMO & Myc-tagged | E.coli | Human | His&Myc&SUMO | 32-240aa |
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| CHRNA3-2775H | Recombinant Human CHRNA3 Protein (32-240 aa), His-tagged | Insect Cell | Human | His | 32-240 aa |
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| CHRNA3-3226HF | Recombinant Full Length Human CHRNA3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 489 amino acids |
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| RFL14526RF | Recombinant Full Length Rat Neuronal Acetylcholine Receptor Subunit Alpha-3(Chrna3) Protein, Tag-Free | E.coli expression system | Rat | Non | Full L. Full Length of Mature Protein (26-499) |
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Involved Pathway
CHRNA3 involved in several pathways and played different roles in them. We selected most pathways CHRNA3 participated on our site, such as Acetylcholine Binding And Downstream Events,Activation of Nicotinic Acetylcholine Receptors,Cholinergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHRNA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuronal System | KCNAB2B,PPFIA1,NSFB,GNGT2B,SLC1A3A,SNAP25B,KCNK7,KCNV2,KCNQ2,PANX1 |
| Neuroactive ligand-receptor interaction | CHRNA6,TRHR2,PTGIR,THRB,PTGER4B,ADRB3B,P2RX4,GRIK4,P2RY6,DRD1B |
| Cholinergic synapse | AKR1C1,PIK3R5,KCNQ1,CREB5,AKT2,KCNJ3,CHRNA6,CREB3L4,PLCB4,GNB4 |
| Activation of Nicotinic Acetylcholine Receptors | CHRNA7,CHRNA4,CHRNA1,CHRNB4,CHRND,CHRNA2,CHRNA5,CHRNE,CHRNB2 |
| Acetylcholine Binding And Downstream Events | CHRNA5,CHRNE,CHRNA7,CHRNB2,CHRNA4,CHRNA2,CHRNA1,CHRND,CHRNB4 |
| Highly calcium permeable nicotinic acetylcholine receptors | CHRNA1,CHRNB2,CHRNB4,CHRNA4,CHRNA5,CHRNA2 |
| Highly sodium permeable acetylcholine nicotinic receptors | CHRNA4,CHRNB2,CHRNB4,CHRND,CHRNE |
| Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | CHRNA7,CHRNA1,CHRNA4,CHRNB4,CHRNA5,CHRNB2,CHRNA2 |
Protein Function
CHRNA3 has several biochemical functions, for example, contributes_to acetylcholine binding,acetylcholine binding,acetylcholine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHRNA3 itself. We selected most functions CHRNA3 had, and list some proteins which have the same functions with CHRNA3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ligand-gated ion channel activity | ANXA6,CNGA3,CLCA2,GABRB1,CHRNA4,CHRNB1,TRPA1B,Chrng,P2RX2,CHRNB4 |
| contributes_to acetylcholine binding | CHRNB1,CHRNA6,CHRNA2A,CHRNA5,CHRND,ZACN,CHRNB3A,CHRNA1,CHRNB1L,CHRNA10A |
| acetylcholine receptor activity | CHRNA2,CHRNA5,CHRNA7,ANXA9,CHRNA4,CHRNB2,CHRNB4,CHRNE,CHRNA6 |
| acetylcholine-activated cation-selective channel activity | CHRNB1L,CHRNB4,CHRNB3B,CHRNA10A,CHRNB3A,CHRNA4,Chrng,CHRNE,CHRND,CHRNA5 |
| protein heterodimerization activity | NTSR1,POLE3,UGT1A2,BCL2L2,H2-Q10,BMP7A,TPD52L2,GRIN2A,CUL3,TTR |
| drug binding | IL2RA,CHRM3,PYGM,MTOR,SFRP1,P2RX4,FABP1,ADRB2,CHKA,CYP4B1 |
| acetylcholine binding | CHRNB3,CHRFAM7A,CHRNB1,CHRNB2,CHRM3,ACHE,CHRNA7,CHRNA4 |
Interacting Protein
CHRNA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHRNA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHRNA3.
CHRNB2;CHRNA5
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References
- Gelernter, J; Kranzler, HR; et al. Genome-Wide Association Study of Nicotine Dependence in American Populations: Identification of Novel Risk Loci in Both African-Americans and European-Americans. BIOLOGICAL PSYCHIATRY 77:493-503(2015).
- Sieminska, A; Jassem, E; et al. Nicotine dependence in an isolated population of Kashubians from North Poland: a population survey. BMC PUBLIC HEALTH 15:-(2015).
