Recombinant Human CFHR5, His-tagged

• Cat.No.: CFHR5-920H
• Product Overview: Recombinant Human CFHR5 (Glu19­Glu569) fused with 10­His tag at C terminal, was expressed in Mouse NSO Cells.

Specification

• Cat. No.: CFHR5-920H
• Description: The human complement factor H protein family consists of the complement and immune regulators factor H, the factor H­like protein 1 and five factor H­ related proteins (FHR­1 to ­5). Members of this family are exclusively composed of individually folded protein domains, termed short consensus repeats (SCRs) or complement control modules. The genes of this family have been located in human chromosome 1q32, which is known as the regulator of complement activation (RCA) gene clusters. FHR­5 has been identified initially as a universal component of complement deposits, and detected in glomerular immune deposit. The pattern of deposits is similar to other complement components, suggesting that FHR­5 may play a role in complement activation and regulation. It is synthesized in the liver and consists of 9 SCRs. Its biological function is not understood fully. FHR­5 exhibits similar characteristics as those of factor H in heparin binding, CRP binding, and lipoprotein association. Weak factor I­dependent cofactor activity for C3b cleavage has also been observed.
• Source: Mammalian cells
• Purity: >90% as determined by SDS-PAGE
• PredictedN terminal: Glu 19
• MolecularMass: Predicted molecular mass of this protein is 64 KDa. It migrates as an approximately 73 KDa band in SDS-PAGE under reducing conditions.
• Formulation: Lyophilized from a 0.2 μm filtered solution in Tris and NaCl.
• Endotoxin: <1.0 EU per 1 μg of the protein as determined by the LAL method.
• Reconstitution: Reconstitute at 100 μg/mL in sterile PBS.
• Activity: Measured by its ability to inhibit the binding of biotinylated Recombinant Human Complement Factor H­related 5/CFHR5 to immobilized Recombinant Human C-Reactive Protein/CRP.
• Storage: 1 year from date of receipt, ­20 to ­70 °C as supplied. Avoid repeatedFreeze/thaw cycles.
• OfficialSymbol: CFHR5
• Tag: Non

Gene Information

• Gene Name: CFHR5 complement factor H-related 5 [ Homo sapiens ]
• Synonyms: FHR5; CFHL5; FHR-5; complement factor H-related protein 5; factor H-related protein 5; complement factor H-related 5
• Gene ID: 81494
• mRNA Refseq: NM_030787
• Protein Refseq: NP_110414
• MIM: 608593
• UniProt ID: Q9BXR6
• Chromosome Location: 1q31.3