CFHR5
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Official Full Name
complement factor H-related 5 -
Overview
This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene;family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein;encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within;repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar;to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent;manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been;associated, but not causally linked, with two different forms of kidney disease: membranoproliferative;glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS). -
Synonyms
FHR5;CFHL5;FHR-5
Recombinant Proteins
- Human
- Mammalian cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- HEK293T
- E.coli
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
CFHR5 involved in several pathways and played different roles in them. We selected most pathways CFHR5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CFHR5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CFHR5 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by CFHR5 itself. We selected most functions CFHR5 had, and list some proteins which have the same functions with CFHR5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
CFHR5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CFHR5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CFHR5.
Resources
Research Area
Serine Proteases and RegulatorsAlternative Complement Pathway
Complement Regulatory Proteins
Related Services
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References
