Recombinant Human CFHR5 Protein (Glu19-Glu569), C-His tagged

• Cat.No.: CFHR5-1002H
• Product Overview: Recombinant human CFHR5 (Glu19-Glu569) fused with the C-terminal His tag was expressed in Mammalian cells.

Specification

• Description: This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS).
• Source: Mammalian cells
• Species: Human
• Tag: His
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 60.61 kDa
• Protein length: Glu19-Glu569
• Purity: >90% as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles.
  Store at 2 to 8 centigrade for one week.
  Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS or lyophilized from PBS.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: CFHR5 complement factor H related 5 [ Homo sapiens (human) ]
• Official Symbol: CFHR5
• Synonyms: CFHR5; complement factor H related 5; FHR5; CFHL5; FHR-5; CFHR5D; complement factor H-related protein 5; factor H-related protein 5
• Gene ID: 81494
• mRNA Refseq: NM_030787
• Protein Refseq: NP_110414
• MIM: 608593
• UniProt ID: Q9BXR6