Recombinant Human CDK12 Protein, GST-tagged

• Cat.No.: CDK12-11H
• Product Overview: Recombinant human CDK12 (658-end) /Cyclin K complex was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag on both proteins.

Specification

• Species: Human
• Source: Insect Cells
• Tag: GST
• ProteinLength: 658-end a.a.
• Description: CDK12 forms a protein complex with cyclin K and this complex acts at the level of RNA polymerase II (RNAPII) to regulate expression of long complex genes, several of which play a role in DNA maintenance and repair. CDK12 is highly expressed in adult liver, kidney, testis, ovary, spinal cord and within specific adult brain regions with the highest expression being detected in cerebellum and caudate nucleus. CYCK-CDK12 and CYCK-CDK13 complexes show unique function with the CYCK-CDK12 playing a role in maintenance of genomic stability.
• Molecular Mass: CDK12 ~135kDa and CyclinK ~67kDa
• Purity: > 80%
• Applications: WB
• Stability: One year at -70 centigrade from data of shipment.
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: >0.1 μg/μL

Gene Information

• Gene Name: CDK12 cyclin dependent kinase 12 [ Homo sapiens (human) ]
• Official Symbol: CDK12
• Synonyms: CDK12; cyclin dependent kinase 12; CRK7; CRKR; CRKRS; cyclin-dependent kinase 12; CDC2-related protein kinase 7; Cdc2-related kinase, arginine/serine-rich; cell division cycle 2-related protein kinase 7; cell division protein kinase 12; EC 2.7.11.22; EC 2.7.11.23
• Gene ID: 51755
• mRNA Refseq: NM_016507
• Protein Refseq: NP_057591
• MIM: 615514
• UniProt ID: Q9NYV4