CDK12
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Official Full Name
cyclin-dependent kinase 12 -
Overview
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway. -
Synonyms
CRK7;CRKR;CRKRS;hCDK12;KIAA0904;cyclin-dependent kinase 12;OTTHUMP00000164282;CDC2-related protein kinase 7;cell division protein kinase 12;Cdc2-related kinase, arginine/serine-rich;cell division cycle 2-related protein kinase 7
Recombinant Proteins
- Rat
- Human
- Mouse
- Rhesus macaque
- Fruit fly
- Mammalian Cells
- Insect Cells
- Wheat Germ
- HEK293
- E.coli
- His
- GST
- His&Fc&Avi
- His&Myc
Involved Pathway
CDK12 involved in several pathways and played different roles in them. We selected most pathways CDK12 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CDK12 has several biochemical functions, for example, ATP binding,RNA polymerase II carboxy-terminal domain kinase activity,cyclin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK12 itself. We selected most functions CDK12 had, and list some proteins which have the same functions with CDK12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase activity | FGFR1A,CSNK1E,SBK1,STK24A,PRKCBA,NPR1,CSNK1DB,TNIK,MYO3A,RPS6KAL |
| nucleotide binding | LARP7,RAC3A,RBM39B,PKN1B,SRSF7A,DAPK2A,PRKACBB,ATP2B1A,FPGS,DNM1A |
| RNA polymerase II carboxy-terminal domain kinase activity | CDK8,CDK7,CDK1,CDK13,CDK9,MAPK1,CCNK |
| transferase activity | SULT3ST4,PIGB,INSRA,SMYD2A,B3GALTLB,CHST3A,SUV39H1A,CHATA,LMTK2,UGT2B5 |
| cyclin binding | CDK13,INCA1,CDK2,CDKN1A,CDK5RAP3,CDK4,FBXW7,CDK14,PFTK1,MDFIC |
| ATP binding | ROCK1,CKM,UBE2D1,XRCC2,DHX33,PKM,MAP3K15,VMHC,AMHR2,MYH7B |
| protein serine/threonine kinase activity | MAP3K4,SRPK1A,ERN2,SIK3,LATS2,SIK2A,FAM20C,STK30,CSNK1DB,SLK |
| kinase activity | FYNB,PTK6B,ERBB4A,LMTK2,CDK5R1,ALPK2,MAPK12B,PRPS1L1,SRPK1B,UCKL1A |
| cyclin-dependent protein serine/threonine kinase activity | MOK,CDK7,NAT1,CDK9,CDK17,CCND3,CDK13,CDKL2,CDK11A,CDK8 |
Interacting Protein
CDK12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK12 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK12.
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References
- Rudrabhatla, P; Utreras, E; et al. Regulation of Sox6 by Cyclin Dependent Kinase 5 in Brain. PLOS ONE 9:-(2014).
- Hattori, T; Uchida, C; et al. Distinct and Site-Specific Phosphorylation of the Retinoblastoma Protein at Serine 612 in Differentiated Cells. PLOS ONE 9:-(2014).
