Recombinant Human CD6 Molecule, His-tagged

• Cat.No.: CD6-4759H
• Product Overview: CD6 was fused with a C-terminal 6 His tag and has a calculated MW of 68.2 KDa expressed. Protein migrates as 110 kDa in reduced SDS-PAGE resulting from glycosylation.

Specification

• Cat. No.: CD6-4759H
• Description: CD6 (Cluster of Differentiation 6) is a cell surface glycoprotein that is involved in T cell activation and a member of the scavenger receptor cysteine rich protein superfamily (SRCRSF). CD6 is expressed at low levels on immature thymocytes and at high levels on mature thymocytes. CD6 appears to play a role as both a costimulatory molecule in T cell activation and as an adhesion receptor. Studies demonstrating a mitogenic effect for T cells with some CD6 specific monoclonal antibodies, in conjunction with either accessory cells or PMA and antiCD2 mAb, support the concept of CD6 as a co stimulatory molecule.
• Source: Recombinant human CD6 /TP120 His18 -Glu398 (Accession Q8WWJ7) fused with a C-terminal His tag was produced in human HEK293 cells
• Species: Human
• Form: Bulk protein in a 0.22 μm filtered solution of PBS, pH7.4 and delivered as liquid formulation or lyophilized powder. Normally 5-8% trehalose and mannitol are added as protectants before lyophilization.
• Purity: >95% as determined by SDS-PAGE. All lots are greater than 95% pure.
• Endotoxin: Less than 1.0 EU per 1 μg of the rhCD6 by the LAL method.
• Storage: Store at -80°C upon received. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: CD6 CD6 molecule [ Homo sapiens ]
• Official Symbol: CD6
• Synonyms: CD6; CD6 molecule; TP120; FLJ44171; CD6 antigen; T-cell differentiation antigen CD6; T12; OTTHUMP00000236965; OTTHUMP00000236967; OTTHUMP00000236969; OTTHUMP00000236970; OTTHUMP00000236971
• Gene ID: 923
• mRNA Refseq: NM_006725
• Protein Refseq: NP_006716
• MIM: 186720
• UniProt ID: P30203
• Chromosome Location: 11q13
• Pathway: Cell adhesion molecules (CAMs)
• Function: scavenger receptor activity