Recombinant Human CCND2, His-tagged

• Cat.No.: CCND2-27757TH
• Product Overview: Recombinant full length Human Cyclin D2 with N terminal His tag; 313aa; 35.6 kDa inclusive of tag.

Specification

• Description: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors.
• Protein length: 289 amino acids
• Conjugation: HIS
• Molecular Weight: 35.600kDa inclusive of tags
• Source: E. coli
• Form: Liquid
• Purity: by SDS-PAGE
• Storage buffer: pH: 8.00Constituents:83% Tris HCl, 6% Urea, 0.03% DTT, 10% Glycerol
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MGSHMELLCH EVDPVRRAVR DRNLLRDDRV LQNLLTIEER YLPQCSYFKC VQKDIQPYMR RMVATWMLEVCEEQKCEEEV FPLAMNYLDR FLAGVPTPKS HLQLLGAVCM FLASKLKETS PLTAEKLCIY TDNSIKPQEL LEWELVVLGK LKWNLAAVTPHDFIEHILRK LPQQREKLSL IRKHAQTFIA LCATDFKFAM YPPSMIATGS VGAAICGLQQ DEEVSSLTCD ALTELLAKIT NTDVDCLKACQEQIEAVLLN SLQQYRQDQR DGSKSEDELD QASTPTDVRD IDL
• Sequence Similarities: Belongs to the cyclin family. Cyclin D subfamily.Contains 1 cyclin N-terminal domain.

Gene Information

• Gene Name: CCND2 cyclin D2 [ Homo sapiens ]
• Official Symbol: CCND2
• Synonyms: CCND2; cyclin D2; G1/S-specific cyclin-D2; G1/S specific cyclin D2
• Gene ID: 894
• mRNA Refseq: NM_001759
• Protein Refseq: NP_001750
• MIM: 123833
• Uniprot ID: P30279
• Chromosome Location: 12p13
• Pathway: B Cell Receptor Signaling Pathway, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem
• Function: protein kinase binding