CCND2
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Official Full Name
cyclin D2 -
Overview
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. [provided by RefSeq, Oct 2008] -
Synonyms
CCND2;cyclin D2;KIAK0002;G1/S-specific cyclin-D2;G1/S-specific cyclin D2
Recombinant Proteins
- Human
- Rat
- Mouse
- Chicken
- E.coli
- HEK293
- Wheat Germ
- Mammalian Cells
- Sf9 Cells
- In Vitro Cell Free System
- GST
- His&Avi
- His
- His&T7
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
CCND2 involved in several pathways and played different roles in them. We selected most pathways CCND2 participated on our site, such as FoxO signaling pathway,Cell cycle,p signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCND2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PIK-Akt signaling pathway | PRKAA1,Pdgfa&Pdgfb,IFNA10,ITGA1,RPS6KB1,MTCP1,Il6ra,CRTC2,PRKCA,IL6R |
| Jak-STAT signaling pathway | IL15RA,PIAS1,STAT2,MCL1A,IFNAR1,IL7,IFNA12,CSF3R,IL13RA2,Il23a |
| HTLV-I infection | PIK3R3,ELK4,IKBKB,WNT8B,STAT5B,ANAPC11,WNT7B,IL2RG,APC,PDGFB |
| Measles | NFKBIB,HSPA1L,IL6,OAS2,EIF3H,MX1,Il2,IFIH1,PRKCQ,IL1A |
| FoxO signaling pathway | HOMER3,FOXG1A,MAPK12A,SMAD3,FOXO1A,CCNB1,SMAD2,INS2,FOXO3B,FOXG1 |
| Hippo signaling pathway | FZD10,PPP2R2B,YAP1,WNT4,LATS2,YWHAE,WNT3,BMPR1A,CCND3,FGF1 |
| Cell cycle | SKA1,DYNC1H1,STIL,TGFB1,CUL1A,RAD50,BRE,NUPL2,MCM3L,TBC1D8 |
| MicroRNAs in cancer | GRB2,APC2,TRIM71,MTOR,BRCA1,PRKCA,BMPR2,CCNG1,NOTCH1,PLCG2 |
| Prolactin signaling pathway | CSN2,NRAS,FOXO3,AKT1,SOCS1,INS1,GRB2,TNFRSF11A,PPIB,CSH |
Protein Function
CCND2 has several biochemical functions, for example, protein binding,protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCND2 itself. We selected most functions CCND2 had, and list some proteins which have the same functions with CCND2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ADRA2A,HNRNPM,RHOT2,ARL4A,NFU1,DAG1,FABP5,TBATA,ANKRD54,KIAA1958 |
| protein kinase binding | TCF7L2,MAP2K7,DLG1L,LAT,NSF,RCC2,RPS19,MSH2,CD8A,DPYSL2 |
Interacting Protein
CCND2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCND2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCND2.
CDKN1A;CDK5;PCGF2;CDK4;CDK2;CDKN1B;CDK6
CCND2 Related Signal Pathway
Resources
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References
- Khaidakov, M; Mitra, S; et al. Oxidized LDL Receptor 1 (OLR1) as a Possible Link between Obesity, Dyslipidemia and Cancer. PLOS ONE 6:-(2011).
- Atsaves, V; Lekakis, L; et al. The oncogenic JUNB/CD30 axis contributes to cell cycle deregulation in ALK plus anaplastic large cell lymphoma. BRITISH JOURNAL OF HAEMATOLOGY 167:514-523(2014).
