Recombinant Human CBFA2T3 Protein, MYC/DDK-tagged

• Cat.No.: CBFA2T3-2730H
• Product Overview: Recombinant Human CBFA2T3 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants.
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 71 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 [ Homo sapiens ]
• Official Symbol: CBFA2T3
• Synonyms: ETO2; MTG16; MTGR2; ZMYND4
• Gene ID: 863
• mRNA Refseq: NM_005187
• Protein Refseq: NP_005178
• MIM: 603870
• UniProt ID: O75081