CBFA2T3
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Official Full Name
core-binding factor, runt domain, alpha subunit 2; translocated to, 3 -
Overview
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5-region of the runt-related transcription factor 1 gene fused to the 3-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants. -
Synonyms
CBFA2T3;core-binding factor, runt domain, alpha subunit 2;translocated to, 3;protein CBFA2T3;MTG16;MTGR2;myeloid translocation gene 8 and 16b;ZMYND4;MTG8-related gene 2;MTG8-related protein 2;zinc finger MYND domain-containing protein 4;myeloid
Recombinant Proteins
- Human
- Chicken
- Mouse
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- HEK293T
- GST
- His
- Non
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CBFA2T3-0453H | Recombinant Human CBFA2T3 Protein, GST-Tagged | Wheat Germ | Human | GST |
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| CBFA2T3-2293C | Recombinant Chicken CBFA2T3 | Mammalian Cell | Chicken | His |
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| CBFA2T3-286HCL | Recombinant Human CBFA2T3 cell lysate | Human | Non |
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| CBFA2T3-2730H | Recombinant Human CBFA2T3 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| CBFA2T3-2756HF | Recombinant Full Length Human CBFA2T3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 615 amino acids |
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| CBFA2T3-2858H | Recombinant Human CBFA2T3 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| Cbfa2t3-786M | Recombinant Mouse Cbfa2t3 Protein, MYC/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
CBFA2T3 involved in several pathways and played different roles in them. We selected most pathways CBFA2T3 participated on our site, such as ErbB4 signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with CBFA2T3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ErbB4 signaling events | WWP1,YAP1,WWOX |
Protein Function
CBFA2T3 has several biochemical functions, for example, chromatin binding,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CBFA2T3 itself. We selected most functions CBFA2T3 had, and list some proteins which have the same functions with CBFA2T3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | ZNF189,JUNBB,MYCH,ATF7B,TFDP2,NFKB2,ZNF79,PURBA,RELA,TP63 |
| protein binding | PAGE2,GTF2H4,TFR2,MAP3K1,ARNTL2,HK1,PLXNB2,RB1,SHE,NXF3 |
| metal ion binding | RIOK2,RCVRNA,ZNRF2A,TATDN3,ATP2A2A,ZFP553,MAT2AL,RFNG,ITGB2,DDX11 |
| chromatin binding | NSD1,RDBP,TPR,STAG2,NEUROD1,HOXD13,TOP2A,CCNT1,NR5A2,NSBP1 |
| transcription corepressor activity | RARA,SMARCA4,JUNB,KLF12,YAP1,ID4,RLIM,SKOR1A,ZHX1,HSBP1 |
Interacting Protein
CBFA2T3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CBFA2T3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CBFA2T3.
PLXNA3;ZNF652;Prkar1a;ZBTB47;MATN2;SEC24A;ATN1;cotE;uup3;GMEB2;TRIM33
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