Recombinant Human CBFA2T3 cell lysate

• Cat.No.: CBFA2T3-286HCL

Specification

• Description: The t(16;21)(q24;q22) translocation is a rare but recurrent chromosomal abnormality associated with therapy-related myeloid malignancies. The translocation produces a chimeric gene made up of the 5-region of the AML1 gene fused to the 3-region of this gene. In addition, this gene is a putative breast tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene, and a brefeldin A-sensitive association of RII-alpha protein with one of the isoforms has been demonstrated in the Golgi apparatus.
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot
• Tag: Non

Gene Information

• Gene Name: CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 [ Homo sapiens ]
• Official Symbol: CBFA2T3
• Synonyms: CBFA2T3; core-binding factor, runt domain, alpha subunit 2; translocated to, 3; protein CBFA2T3; MTG16; MTGR2; myeloid translocation gene 8 and 16b; ZMYND4; MTG8-related gene 2; MTG8-related protein 2; zinc finger MYND domain-containing protein 4; myeloid translocation gene on chromosome 16 protein; ETO2
• Gene ID: 863
• mRNA Refseq: NM_005187
• Protein Refseq: NP_005178
• MIM: 603870
• UniProt ID: O75081
• Chromosome Location: 16q24
• Pathway: ErbB4 signaling events, organism-specific biosystem
• Function: chromatin binding; metal ion binding; protein binding; sequence-specific DNA binding transcription factor activity; zinc ion binding