Recombinant Human C3 Protein, His-tagged

• Cat.No.: C3-1149H
• Product Overview: Recombinant Human C3 Protein (26-225aa) was expressed in E. coli with N-terminal His-tag.

Specification

• Source: E. coli
• Species: Human
• Tag: His
• Form: Tris-based buffer, 50% glycerol.
• Molecular Mass: 26.4 kDa
• AA Sequence: YSIITPNILRLESEETMVLEAHDAQ GDVPVTVTVHDFPGKKLVLSSEKTV LTPATNHMGNVTFTIPANREFKSEK GRNKFVTVQATFGTQVVEKVVLVSL QSGYLFIQTDKTIYTPGSTVLYRIF TVNHKLLPVGRTVMVNIENPEGIPV KQDSLSSQNQLGVLPLSWDIPELVN MGQWKIRAYYENSPQQVFSTEFEVK
• Purity: Greater than 90% as determined by SDS-PAGE.
• Storage: The shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Protein length: 26-225

Gene Information

• Gene Name: C3 complement C3 [ Homo sapiens (human) ]
• Official Symbol: C3
• Synonyms: ASP; C3a; C3b; AHUS5; ARMD9; CPAMD1; HEL-S-62p; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; C3a anaphylatoxin; acylation-stimulating protein cleavage product; complement component 3; complement component C3a; complement component C3b; epididymis secretory sperm binding protein Li 62p; prepro-C3; complement C3
• Gene ID: 718
• mRNA Refseq: NM_000064.3
• Protein Refseq: NP_000055.2
• UniProt ID: P01024

Reviews

02/23/2022

Expression efficiency is high. In our experiments, we found that the target protein can be synthesized quickly and effectively.

01/26/2022

Activity was not significantly different from the native protein, as expected.

03/23/2021

High purity, no obvious impurities.

Q&As

Have proteins been found to interact with C3 proteins?

Yes, a variety of proteins that interact with C3 proteins, including complement receptors, regulatory proteins, inflammatory factors, etc., have been discovered, and they are jointly involved in the regulation and functional execution of C3 proteins.

What is the relationship between C3 protein and infectious diseases?

C3 protein plays an important role in infectious diseases. It can play an anti-infection role by activating the complement system, directly killing pathogens or enhancing the ability of immune cells to destroy pathogens.

How is the research progress of C3 protein at present?

Research on C3 protein is going on. At present, it mainly focuses on the analysis of its function and regulatory mechanism, the identification of gene mutations associated with diseases, and the interaction with other complement proteins and immune cells, which provides a theoretical basis for the further development of diagnosis and treatment methods of related diseases.

What is the use of C3 protein in laboratory diagnostics?

C3 protein can be used as an aid in the diagnosis of certain immune-related diseases. Measuring the level of C3 protein in serum can reflect the activity of the immune system and the degree of inflammation.

What are the effects of post-translational modifications of C3 protein on its function?

Post-translational modifications of the C3 protein can affect its function. Phosphorylation, cleavage, methylation and other modifications can regulate the activity, stability and interaction ability of C3 proteins.

Have any drug treatments associated with C3 protein been identified?

Yes, some C3 protein-related drug treatments are under development, including drugs that regulate the degree of C3 protein activation, drugs that inhibit the overactivation of C3 protein, etc.