C3

  • Official Full Name

    complement component 3

  • Overview

    C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.

  • Synonyms

    complement C3;Acylation Stimulating Protein Cleavage Product;ASP;C3 and PZP like alpha 2 macroglobulin domain containing protein 1;C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1;C3;CO3_HUMAN;Complement C3 precursor;Complement C3c alpha'' chain fragment 2;Complement Component 3;Complement factor 3;CPAMD 1;CPAMD1

Recombinant Proteins

  • Human
  • Rabbit
  • Swine
  • C.botulinum
  • Cynomolgus
  • Clostridium Botulinum
  • Rat
  • Mouse
  • Pig
  • Chicken
  • Monkey
  • Cattle
  • Bovine
  • E.coli
  • HEK293
  • Yeast
  • C. botulinum
  • Clostridium botulinum D bacteriophage
  • Human Serum
  • Mammalian Cell
  • Human serum
  • Normal rabbit serum from healthy animals of mixed gender
  • Normal cynomolgus serum from healthy animals of mixed gender
  • Normal mouse serum from healthy animals of mixed gender
  • Normal rat serum from healthy animals of mixed gender
  • Human Plasma
  • HEK293T
  • Mammalian cells
  • Plasma
  • His
  • Non
  • His&GST
  • His&T7
  • Myc&DDK
  • His&Avi
  • Flag
  • His&SUMO
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
C3-10522H Recombinant Human C3, His-tagged E.coli Human His C-term-350a.a.
C3-10H Active Recombinant Human C3 protein, His-tagged HEK293 Human His Ser 23 - Asn 1663
C3-4324R Recombinant Rabbit C3 Protein Yeast Rabbit Non 77aa
C3-4325S Recombinant Swine C3 Protein Yeast Swine Non 77aa
C3-603H Active Recombinant Human C3 E.coli Human Non 672-748 a.a.
C3-001C Active Native C. botulinum C3 Enzyme C. botulinum C.botulinum Non
C3-01H Active Recombinant Human C3 Protein E.coli Human Non 672-748 a.a.
C3-114C Active Recombinant Cynomolgus C3 protein, His-tagged HEK293 Cynomolgus His Thr 23 - Asn 1663
C3-147C Active Native Botulinum C3 Enzyme Clostridium botulinum D bacteriophage Clostridium Botulinum Non
C3-365H Active Native Human C3 Protein Human Serum Human Non
C3-1050R Recombinant Rat C3 Protein Mammalian Cell Rat His
C3-1149H Recombinant Human C3 Protein, His-tagged E.coli Human His 26-225 a.a.
C3-558H Recombinant Human C3 Protein, His/GST-tagged E.coli Human His&GST Ser672~Arg748
C3-559M Recombinant Mouse C3 Protein, His/GST-tagged E.coli Mouse His&GST Ser671~Arg748
C3-560P Recombinant Pig C3 Protein, His/GST-tagged E.coli Pig His&GST Ser670~Leu742
C3-561R Recombinant Rat C3 Protein, His/GST-tagged E.coli Rat His&GST Ser671~Arg748
C3-6956C Recombinant Chicken C3 Mammalian Cell Chicken His
C3-7631H Recombinant Human C3 protein, His-tagged E.coli Human His Glu1322~Cys1661
C3-7632M Recombinant Mouse C3 protein, His-tagged E.coli Mouse His Ala965-Arg1303
C3-7842H Recombinant Human C3 protein, His-tagged E.coli Human His Leu1000~Glu1326
C3-7843M Recombinant Mouse C3 protein, His-tagged E.coli Mouse His Glu1314~Asn1663
C3-7844P Recombinant Pig C3 protein, His & T7-tagged E.coli Pig His&T7 Asp23~Thr300
C3-7845R Recombinant Rat C3 protein, His-tagged E.coli Rat His Asp966~Trp1313
C3-012H Native Human Complement C3c Human serum Human
C3-01R Native Rabbit C3 Protein Normal rabbit serum from healthy animals of mixed gender Rabbit
C3-02M Native Monkey C3 Protein Normal cynomolgus serum from healthy animals of mixed gender Monkey
C3-05M Native Mouse C3 Protein Normal mouse serum from healthy animals of mixed gender Mouse
C3-08R Native Rat C3 Protein Normal rat serum from healthy animals of mixed gender Rat
C3-1841H Recombinant Human C3 Protein, MYC/DDK-tagged HEK293 Human Myc&DDK
C3-1859H Active Recombinant Human C3 protein, His-Avi-tagged, Biotinylated HEK293 Human His&Avi Ser 23 - Asn 1663
C3-1944M Recombinant Mouse C3 protein, His-tagged HEK293 Mouse His Ile 25 - Asn 1663
C3-194H Native Human Complement C3c Human Plasma Human Non
C3-2212H Recombinant Human C3 Protein (Ser672-Arg748) E.coli Human Non Ser672-Arg748
C3-2505H Recombinant Human C3 protein(961-1040 aa), C-His-tagged E.coli Human His 961-1040 aa
C3-3052H Recombinant Human C3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
C3-338C Recombinant Cattle C3 Protein, His-tagged E.coli Cattle His Gly448-Thr665
C3-33M Mouse C3 Reference Standard Mouse Non
C3-365HFL Recombinant Full Length Human C3 Protein, C-Flag-tagged Mammalian cells Human Flag Full L.
C3-4246M Recombinant Mouse C3 protein, His-SUMO-tagged E.coli Mouse His&SUMO 1321-1663aa
C3-4464B Recombinant Bovine C3 protein, His-SUMO-tagged E.coli Bovine His&SUMO 747-953aa
C3-471H Recombinant Human C3 Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
C3-471H-B Recombinant Human C3 Protein Pre-coupled Magnetic Beads HEK293 Human
C3-5695R Recombinant Rat C3 protein, His-tagged Yeast Rat His 671-746aa
C3-708R Recombinant Rat C3 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
C3-708R-B Recombinant Rat C3 Protein Pre-coupled Magnetic Beads HEK293 Rat
C3-732M Recombinant Mouse C3 Protein, MYC/DDK-tagged HEK293T Mouse Myc&DDK
C3-73R Rat C3 Reference Standard Rat Non
C3-7H Active Human C3 Reference Standard Human Non
C3-8092H Native Human Plasma COMPLEMENT C (C3) Human Plasma Human Non
C3-8391H Native Human C3 Plasma Human Non

    Involved Pathway

    C3 involved in several pathways and played different roles in them. We selected most pathways C3 participated on our site, such as Phagosome,Complement and coagulation cascades,Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with C3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Leishmaniasis IFNGR1,NCF1,NFKB1,HLA-DRB3,NFKBIA,Itgam&Itgb2,HLA-DQB1,IL1A,TAB2,FCGR1
    Systemic lupus erythematosus GM14479,HLA-DOA,HIST1H4C,TRIM21,HLA-DQB1,C4A,HLA-DQA2,HIST1H2BI,ACTN3,H2AFJ
    Complement and coagulation cascades PROC,PLG,C4A,Hc,PROS1,THBD,C4BPA,C9,SERPIND1,C3AR1
    Herpes simplex infection CRFB2,IL12B,BLA,CLOCKB,IL12A,PKZ,IFNA1,IFNA3,SRSF5,LOC100033925
    Viral carcinogenesis PIK3R2,HIST1H2BB,CCND1,EP300,HDAC1,KAT2B,SRC,CREB5,HLA-B,HIST1H4E
    Staphylococcus aureus infection H2-AA,HLA-DQA1,C4A,SELPLG,MASP1,ITGB2L,FCGR1A,FPR2,FPR3,DSG1C
    Chagas disease (American trypanosomiasis) PIK3R3,GNAI3,CASP8,RELA,CCL3L3,BDKRB2,MAPK9,SERPINE1,CALR,Il2
    Pertussis TLR4,MAPK11,C4A,Il23a; Il12b,TICAM2,RELA,GM5077,Casp3,CASP7,C2
    Tuberculosis Ifna15,CALM4,CALML5,BID,IFNA17,HLA-DRA,KSR1,FCGR3B,AKT1,IL18

    Protein Function

    C3 has several biochemical functions, for example, C5L2 anaphylatoxin chemotactic receptor binding,cofactor binding,endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by C3 itself. We selected most functions C3 had, and list some proteins which have the same functions with C3. You can find most of the proteins on our site.

    Function Related Protein
    protein binding PSMC1,LGI1,SMNDC1,RYK,LRP2BP,GTPBP3,FOXM1,LCORL,CSE1L,FRA10AC1
    cofactor binding HACL1,TKT,PGAM2,ASNS,ME3,TYMS,UROS,ACLY,WWOX,LMO2
    endopeptidase inhibitor activity C3A.6,PCSK1N,C3P1,LPA,Cstb,STFA1,SLPI,SERPINA1A,SERPIND1,A1i3
    lipid binding SH3GL2,BPIFB2,APOE,APOL2,TRIP10,PITPNM3,STARD7,CRABP1B,RBP2A,APODA.2
    receptor binding AGXT,MLYCD,PTK2B,PEX14,IL29,ARPP19A,HIST2H3C2,CD160,PTPRD,PPP2R4

    Interacting Protein

    C3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with C3 here. Most of them are supplied by our site. Hope this information will be useful for your research of C3.

    VSIG4;VSIG4;CD46;d3jib2_staau;IGM;VHL;ASF1B;TGM2;q99ib8-pro_0000045598;q99ib8-pro_0000045601;d-mannose;crlkekhc;IGHM

    Resources

    Research Area

    Serine Proteases and Regulators
    Adipocytokines
    Alternative Complement Pathway
    Classical Complement Pathway

    References

    • Ohta, T; Urayama, K; et al. Eculizumab in the treatment of atypical hemolytic uremic syndrome in an infant leads to cessation of peritoneal dialysis and improvement of severe hypertension. PEDIATRIC NEPHROLOGY 30:603-608(2015).
    • Yue, PJ; He, L; et al. Long-term toxicity study of rAd5-hTERTC27 in SD rats and Cynomolgus monkeys by intravenous injection. REGULATORY TOXICOLOGY AND PHARMACOLOGY 71:285-294(2015).

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