Recombinant Human C2
| Cat.No. : | C2-26739TH |
| Product Overview : | Recombinant fragment of Human C2 with N terminal proprietary tag, 49kDa. |
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| Description : | Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined. |
| Molecular Weight : | 49.000kDa |
| Source : | E. coli |
| Form : | Lyophilised:Add 200ul of distilled water. |
| Storage buffer : | pH: 6.80Constituents:1.58% Tris HCl, 3.09% DTT, 4% SDS, 0.2% Bromophenol blue, 20% Sucrose |
| Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. |
| Sequence Similarities : | Belongs to the peptidase S1 family.Contains 1 peptidase S1 domain.Contains 3 Sushi (CCP/SCR) domains.Contains 1 VWFA domain. |
| Tag : | Non |
| Gene Name | C2 complement component 2 [ Homo sapiens ] |
| Official Symbol | C2 |
| Synonyms | C2; complement component 2; complement C2; |
| Gene ID | 717 |
| mRNA Refseq | NM_000063 |
| Protein Refseq | NP_000054 |
| MIM | 613927 |
| Uniprot ID | P06681 |
| Chromosome Location | 6p21.3 |
| Pathway | Activation of C3 and C5, organism-specific biosystem; Complement Activation, Classical Pathway, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; |
| Function | peptidase activity; serine-type endopeptidase activity; |
Not For Human Consumption!
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