C2
-
Official Full Name
complement component 2 -
Overview
Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provided by RefSeq, Mar 2009] -
Synonyms
C2;complement component 2;CO2;ARMD14;complement C2;C3/C5 convertase;complement component C2
Recombinant Proteins
- Human
- Mouse
- Rat
- Cynomolgus
- Glycine max
- HEK293
- Mammalian cells
- Normal human serum (shown by certified tests to be negative for HBsAg and for antibodies to HCV, HIV-1 and HIV-II)
- E.coli
- Human Cell
- His
- Non
- Fc
- His&T7
- His&Fc&Avi
- N-His&C-HA
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| C2-6878H | Active Recombinant Human C2 protein(Met1-Leu752), His-tagged | HEK293 | Human | His | Met1-Leu752 | |
| C2-1012M |
Active Recombinant Mouse C2 Protein, His-tagged
|
Mammalian cells | Mouse | His | Met1-Leu760 |
|
| C2-98H |
Active Native Human C2 Protein
|
Normal human serum (shown by certified tests to be negative for HBsAg and for antibodies to HCV, HIV-1 and HIV-II) | Human | Non |
|
|
| C2-26739TH | Recombinant Human C2 | E.coli | Human | Non |
|
|
| C2-480M | Recombinant Mouse C2, His-tagged | Human Cell | Mouse | His | Met1-Leu760 |
|
| C2-598H | Recombinant Human Complement Component 2, His-tagged | HEK293 | Human | His |
|
|
| C2-599H | Recombinant Human Complement Component 2, Fc Chimera | HEK293 | Human | Fc |
|
|
| C2-7265H | Recombinant Human C2 protein, hFc-tagged | HEK293 | Human | Fc | Met1-Leu752 |
|
| C2-7846H | Recombinant Human C2 protein, His & T7-tagged | E.coli | Human | His&T7 | Ile245~His451 |
|
| C2-7847R | Recombinant Rat C2 protein, His & T7-tagged | E.coli | Rat | His&T7 | Asn473~Arg723 |
|
| C2-001MCL | Recombinant Mouse C2 cell lysate | Human Cell | Mouse | Non |
|
|
| C2-3068HCL | Recombinant Human C2 cell lysate | Human Cell | Human | Non |
|
|
| C2-0620H | Recombinant Human C2 Protein (Ile245-His451), N-His-tagged | E.coli | Human | His | Ile245-His451 |
|
| C2-1032H | Active Recombinant Human C2 protein, His-tagged | HEK293 | Human | His | 21-752 a.a. |
|
| C2-1143M | Recombinant Mouse C2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
|
| C2-1143M-B | Recombinant Mouse C2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
||
| C2-1878C | Active Recombinant Cynomolgus C2 protein, His-tagged | HEK293 | Cynomolgus | His | Ala 21 - Leu 752 |
|
| C2-773G | Recombinant Glycine max Leghemoglobin C2, His&HA-tagged | E.coli | Glycine max | N-His&C-HA | 2-145aa |
|
Involved Pathway
C2 involved in several pathways and played different roles in them. We selected most pathways C2 participated on our site, such as Complement and coagulation cascades,Pertussis,Staphylococcus aureus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with C2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Systemic lupus erythematosus | Hc,HIST1H4I,C8A,H2-AA,HIST1H4N,C9,H2AFJ,FCGR3A,H2AFY,HIST1H4H |
| Staphylococcus aureus infection | FCGR3A,DSG1A,FPR1,SELPLG,PTAFR,ITGAM,C3,CFI,HLA-DOA,ITGB2 |
| Complement and coagulation cascades | FGA,C9,C1QC,F11,CD46,KNG1,C4BP,C8B,F12,FGB |
| Pertussis | RHOA,MAPK13,C4BPA,NLRP3,TICAM2,MAPK9,IL1A,IRAK4,C4BPB,IL6 |
Protein Function
C2 has several biochemical functions, for example, metal ion binding,serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by C2 itself. We selected most functions C2 had, and list some proteins which have the same functions with C2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | ZNF771,AMY2B,CHORDC1B,ZNF410,SP4,GMIP,PRUNE2,ACVRL1,ZFP865,KAT5 |
| serine-type endopeptidase activity | HGFA,KLK1B16,CELA3B,HTRA4,CTRB1,FAP,MCPT2,HGF,C1RA,APEH |
Interacting Protein
C2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with C2 here. Most of them are supplied by our site. Hope this information will be useful for your research of C2.
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References
- Kahle, J; Orlowski, A; et al. Epitope mapping via selection of anti-FVIII antibody-specific phage-presented peptide ligands that mimic the antibody binding sites. THROMBOSIS AND HAEMOSTASIS 113:396-405(2015).
- Shetty, KA; Kosloski, MP; et al. Soy Phosphatidylinositol Containing Nanoparticle Prolongs Hemostatic Activity of B-Domain Deleted Factor VIII in Hemophilia A Mice. JOURNAL OF PHARMACEUTICAL SCIENCES 104:388-395(2015).
