Recombinant Human ATP6V1C2, GST-tagged

• Cat.No.: ATP6V1C2-10044H
• Product Overview: Recombinant Human ATP6V1C2 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A,three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain C subunit isoforms.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 1-381a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: ATP6V1C2 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 [ Homo sapiens ]
• Official Symbol: ATP6V1C2
• Synonyms: ATP6V1C2; ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2; ATPase, H+ transporting, lysosomal 42kD, V1 subunit C isoform 2 , ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C isoform 2; V-type proton ATPase subunit C 2; ATP6C2; VMA5; V-ATPase C2 subunit; V-ATPase subunit C 2; vacuolar proton pump subunit C 2
• Gene ID: 245973
• mRNA Refseq: NM_001039362
• Protein Refseq: NP_001034451
• UniProt ID: Q8NEY4
• Chromosome Location: 2p25.1
• Pathway: Collecting duct acid secretion, organism-specific biosystem; Collecting duct acid secretion, conserved biosystem; Epithelial cell signaling in Helicobacter pylori infection, organism-specific biosystem; Epithelial cell signaling in Helicobacter pylori infection, conserved biosystem; Insulin receptor recycling, organism-specific biosystem; Iron uptake and transport, organism-specific biosystem; Metabolic pathways, organism-specific biosystem
• Function: hydrogen-exporting ATPase activity, phosphorylative mechanism; hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances