ATP6V1C2
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Official Full Name
ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 -
Overview
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A,three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain C subunit isoforms. -
Synonyms
ATP6V1C2;ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2;ATPase, H+ transporting, lysosomal 42kD, V1 subunit C isoform 2 , ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C isoform 2;V-type proton ATPase subunit C 2;ATP6C2;VMA5;ATPase H+ transporting lysosomal 42kDa V1 subunit C2;V ATPase C2 subunit;V ATPase subunit C 2;V type proton ATPase subunit C 2;V-ATPase subunit C 2;Vacuolar ATP synthase subunit C 2;Vacuolar H+ ATPase C2;Vacuolar proton pump subunit C 2;VATC2_HUMAN;VMA 5;OTTHUMP00000115522;OTTHUMP00000200400;V-ATPase C2 subunit
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
ATP6V1C2 involved in several pathways and played different roles in them. We selected most pathways ATP6V1C2 participated on our site, such as Oxidative phosphorylation,Metabolic pathways,Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6V1C2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Collecting duct acid secretion | ATP6V1F,ATP6V1G1,ATP6V1B2,TCIRG1,ATP6V1E1,ATP6V0A2,ATP6V1G2,ATP6V0D1,ATP6V1E2,SLC12A7 |
| Synaptic vesicle cycle | STXBP1,STX3,ATP6V1A,ATP6V0A2,VAMP2,NSF,ATP6V1C1,CPLX2,ATP6V1B2,ATP6V0D2 |
| Phagosome | ITGB3B,CALR3B,CTSL1B,ATP6V1D,TUBA8L3,HLA-DRA,TUBA1C,H2-Q10,HLA-DMA,TUBAL3 |
| Epithelial cell signaling in Helicobacter pylori infection | JAM3,MET,PLCG1,MAPK12,CXCR1,ATP6V1H,IL-8,ATP6V1G3,IKBKG,ADAM17 |
| Oxidative phosphorylation | NDUFS3,COX5AA,ATP5G1,ATP5L,NDUFS5,NDUFS2,ATP5G3A,ATP6V0CA,NDUFA6,NDUFS8B |
| Rheumatoid arthritis | CCL20,CD28,CCL3L1,ITGB2L,CCL3,ATP6AP1,ATP6V1G1,HLA-DOB,VEGFA,HLA-DRB5 |
| Vibrio cholerae infection | ATP6V1G1,PRKACG,ATP6V1E2,ATP6V0D1,ACTB,ACTG1,KDELR3,ATP6V1E1,KDELR1,PLCG1 |
| Metabolic pathways | GCDHB,IDO1,POLR2E,CELL,SPTLC1,NME5,CYP26C1,HPD,FUT4,CYP2B6 |
Protein Function
ATP6V1C2 has several biochemical functions, for example, hydrogen-exporting ATPase activity, phosphorylative mechanism,protein binding,protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6V1C2 itself. We selected most functions ATP6V1C2 had, and list some proteins which have the same functions with ATP6V1C2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hydrogen-exporting ATPase activity, phosphorylative mechanism | ATP6V0D1,ATP6V1E2,ATP6V1G1,ATP6V1E1,ATP6V1G3,ATP6V1C1 |
| protein binding | COA6,IL6R,TGIF1,HGD,PTGFRN,CDPF1,PIK3IP1,VLDLR,PRKAA1,SOD1 |
| protein dimerization activity | MAX,GRIN2A,TAL2,HPSE,HES2.1,ANO4,SRFB,GARS,HES7,EPAS1B |
Interacting Protein
ATP6V1C2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6V1C2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6V1C2.
GOLGA2;q81l81_bacan;pi3p;ATP6V1G1;ATP6V1B2;ATP6V1A;MAGEA6;MRPS9;TTC9C;ECSIT
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References
- Ropka-Molik, K; Zukowski, K; et al. Comprehensive analysis of the whole transcriptomes from two different pig breeds using RNA-Seq method. ANIMAL GENETICS 45:674-684(2014).
- Kandil, OM; Ghanem, N; et al. Transcriptional Analysis of Buffalo (Bubalus bubalis) Oocytes During In Vitro Maturation Using Bovine cDNA Microarray. REPRODUCTION IN DOMESTIC ANIMALS 45:63-74(2010).
