Recombinant Human ARHGAP4, GST-tagged

• Cat.No.: ARHGAP4-9827H
• Product Overview: Recombinant Human ARHGAP4 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins belonging to the RAS superfamily. The protein encoded by the orthologous gene in rat is localized to the Golgi complex and can redistribute to microtubules. The rat protein stimulates the activity of some Rho GTPases in vitro. Genomic deletions of this gene and a neighboring gene have been found in patients with nephrogenic diabetes insipidus. Multiple transcript variants encoding different isoforms have been found for this gene.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 714-986a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: ARHGAP4 Rho GTPase activating protein 4 [ Homo sapiens ]
• Official Symbol: ARHGAP4
• Synonyms: ARHGAP4; Rho GTPase activating protein 4; rho GTPase-activating protein 4; C1; KIAA0131; p115; Rho GAP hematopoietic protein C1; RhoGAP4; SrGAP4; Rho-GAP hematopoietic protein C1; rho-type GTPase-activating protein 4; RGC1
• Gene ID: 393
• mRNA Refseq: NM_001164741
• Protein Refseq: NP_001158213
• MIM: 300023
• UniProt ID: P98171
• Chromosome Location: Xq28
• Pathway: Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem; G alpha (12/13) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; NRAGE signals death through JNK, organism-specific biosystem; Regulation of RhoA activity, organism-specific biosystem; Rho GTPase cycle, organism-specific biosystem; Signal Transduction, organism-specific biosystem
• Function: GTPase activator activity; Rho GTPase activator activity; SH3/SH2 adaptor activity; protein binding