ARHGAP4
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Official Full Name
Rho GTPase activating protein 4 -
Overview
This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins belonging to the RAS superfamily. The protein encoded by the orthologous gene in rat is localized to the Golgi complex and can redistribute to microtubules. The rat protein stimulates the activity of some Rho GTPases in vitro. Genomic deletions of this gene and a neighboring gene have been found in patients with nephrogenic diabetes insipidus. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ARHGAP4;Rho GTPase activating protein 4;rho GTPase-activating protein 4;ARHGAP 4;C1;KIAA0131;OTTHUMP00000026004;p115;RGC 1;RGC1;Rho GAP hematopoietic protein C1;Rho type GTPase activating protein 4;RhoGAP 4;RhoGAP4;OTTHUMP00000026003;OTTHUMP00000063090;OTTHUMP00000196209;OTTHUMP00000198723;Rho-GAP hematopoietic protein C1;rho-type GTPase-activating protein 4;SrGAP4
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ARHGAP4-9827H | Recombinant Human ARHGAP4, GST-tagged | E.coli | Human | GST | 714-986a.a. | |
| ARHGAP4-26278TH | Recombinant Human ARHGAP4, His-tagged | E.coli | Human | His | 692-946 a.a. |
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| ARHGAP4-770H | Recombinant Human ARHGAP4 protein, GST-tagged | Wheat Germ | Human | GST |
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| ARHGAP4-113HCL | Recombinant Human ARHGAP4 cell lysate | Human | Non |
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Involved Pathway
ARHGAP4 involved in several pathways and played different roles in them. We selected most pathways ARHGAP4 participated on our site, such as Cell death signalling via NRAGE, NRIF and NADE,G alpha (12/13) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGAP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GPCR downstream signaling | RLN3,PTHRP2,KALRNB,OPN1SW,OPN4B,OR52J3,TAC1,DCLRE1B,PENKA,GRP |
| Signaling by GPCR | CCL35.1,EDNRAB,NTS,SST1.1,OPN1SW1,GPR65,RGS1,PPY,PROK1,EMR2 |
| NRAGE signals death through JNK | AATF,FGD2,ARHGEF18A,MCF2L,ARHGEF16,ARHGAP4A,AKAP13,ARHGEF9,TIAM2,ARHGEF18 |
| Signal Transduction | CNGA1,PYYA,HHAT,ARHGAP26,RBBP5,DRAP1,SRY,OR10A5,CDH5,TNKS |
| Cell death signalling via NRAGE, NRIF and NADE | BCL2L11,ARHGAP4A,ECT2,TRIO,AKAP13,ARHGEF18,ARHGEF16,ARHGEF1A,NET1,ARHGEF9 |
| Regulation of RhoA activity | ARHGEF10,OBSCN,DEF6,MCF2L,ECT2,MYO9B,NET1,PLEKHG6,ARHGEF28,DLC1 |
| Rho GTPase cycle | ARHGAP12B,ARHGAP12,GDI2,ARHGEF18,RHOT1B,TAGAPA,CHN1,DLC1,ARHGAP6,FGD2 |
| G alpha (12/13) signalling events | FGD2,TIAM2,DCLRE1B,ARHGAP4A,ARHGEF18,FGD4,ARHGEF16,ADRA1D,KALRN,ECT2 |
Protein Function
ARHGAP4 has several biochemical functions, for example, GTPase activator activity,Rac GTPase binding,SH3/SH2 adaptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGAP4 itself. We selected most functions ARHGAP4 had, and list some proteins which have the same functions with ARHGAP4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CADM1,FUT11,ZNF385C,SMARCC2,SNCA,DCTN2,KRTAP10-7,FANCC,DTNB,TP73 |
| Rac GTPase binding | ITPKA,PKN1,PAK2,ARHGEF2,RAB7A,RCC2,SRGAP3,OCRL,ARFIP2,ARHGAP4A |
| GTPase activator activity | TSC2,RGS9B,TBC1D3,STXBP5L,ADAP2,TBC1D30,ARHGAP33,ASAP1,ACAP3,GIT2 |
| SH3/SH2 adaptor activity | NCK1,SKAP1,NCK2,SLA2,ITSN2,GAB1,PAG1,STAM,KHDRBS1,SH2D1A |
Interacting Protein
ARHGAP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGAP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGAP4.
FASLG;ftsZ;rdgC;15-deoxy-delta(12,14
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References
- Jarius, S; Scharf, M; et al. Antibodies to the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in cerebellar ataxia. Journal of Neuroinflammation 11:-(2014).
- Abolghait, SK; Iida, T; et al. Recombinant AexU effector protein of Aeromonas veronii bv. sobria disrupts the actin cytoskeleton by downregulation of Rac1 and induces direct cytotoxicity to beta 4-integrin expressing cell lines. MICROBIAL PATHOGENESIS 51:454-465(2011).
