Recombinant Human Aprataxin, His-tagged

Cat.No. : APTX-1935H
Product Overview : Recombinant Aprataxin protein fused to his-tag was expressed inE.coliand purified by using conventional chromatography techniques. 23.9kDa (205aa).
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Species : Human
Source : E.coli
Tag : His
Description : Aprataxin is a member of the histidine triad (HIT) superfamily, some of which have nucleotide-binding and diadenosine polyphosphate hydrolase activities. Aprataxin may play a role in single-stranded DNA repair. Mutations in the gene have been associated with neurological disorder known as ataxia oculomotor apraxia-1.
Purity : > 95% by SDS – PAGE.
Physical Appearance : Liquid.
Formulation : Liquid. 20mM Tris-HCl buffer (pH7.5) containing 20% glycerol,100mM NaCl, 0.1mM PMSF.
Concentration : 0.25 mg/ml (determined by Bradford assay).
Sequences Of Amino Acids : MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWAGSMQD PKM QVY KDEQ VVVIKDKYPK ARYHWLVLPW TSISSLKAVA REHLELLKHMHTVGEKVIVD FAGSSKLRFR LGYHAIPSMS HVHLHVISQD FDSPCLKNKK HWNSFNTEYF LE SQAVIEMV QEAGRVTVRD GMPELLKLPLRCHECQQ LLP SIPQ LKEHL R KH WT Q.
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name APTX aprataxin [ Homo sapiens ]
Synonyms APTX; aprataxin; AOA; AOA1; AXA1; EAOH; EOAHA; FHA-HIT; MGC1072; FLJ20157; forkhead-associated domain histidine triad-like protein; ataxia 1, early onset with hypoalbuminemia
Gene ID 54840
mRNA Refseq NM_017692
Protein Refseq NP_060162
MIM 606350
UniProt ID Q7Z2E3
Chromosome Location 9p13.3
Function DNA 5"-adenosine monophosphate hydrolase activity;chromatin binding;damaged DNA binding;double-stranded DNA binding;double-stranded RNA binding;hydrolase activity;metal ion binding;phosphoglycolate phosphatase activity;protein N-terminus binding;protein binding;zinc ion binding

Not For Human Consumption!

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