APTX
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Official Full Name
aprataxin -
Overview
This gene encodes a member of the histidine triad (HIT) superfamily. The encoded protein may play a role in single-stranded DNA repair through its nucleotide-binding activity and its diadenosine polyphosphate hydrolase activity. Mutations in this gene have been associated with ataxia-ocular apraxia. Alternatively spliced transcript variants have been identified for this gene. -
Synonyms
APTX;aprataxin;ataxia 1, early onset with hypoalbuminemia , AXA1;AOA;AOA1;EAOH;EOAHA;FLJ20157;AOA 1;Aprataxin homolog;Ataxia 1 early onset with hypoalbuminemia;Ataxia1 early onset with hypoalbuminemia;AXA 1;AXA1;FHA HIT;Forkhead associated domain histidine triad like;Forkhead associated domain histidine triad like protein;MGC1072;forkhead-associated domain histidine triad-like protein;FHA-HIT
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Chicken
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- In Vitro Cell Free System
- HEK293
- His
- Non
- T7
- GST
- His&Fc&Avi
Involved Pathway
APTX involved in several pathways and played different roles in them. We selected most pathways APTX participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with APTX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
APTX has several biochemical functions, for example, DNA 5-adenosine monophosphate hydrolase activity,chromatin binding,damaged DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APTX itself. We selected most functions APTX had, and list some proteins which have the same functions with APTX. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| double-stranded DNA binding | MTERF2,AIM2,SMAD2,KLF6,TP53,MTERF3,FEV,PNKP,RAD51C,EGFR |
| phosphoprotein binding | DPYS,RB1,CBX4,URI1,CACNB2,SNCA,ARR3,TBL2,PKD2,MID1 |
| protein binding | C1orf21,KIF3A,NCS1,HMBOX1,RBBP5,ITGB3B,SRSF3,TADA3,FANCG,OLIG1 |
| metal ion binding | ATP8A1,ZNF653,ZNF576.2,CMTM2A,ATP2B4,SH3RF3,E4F1,ZNF397,TRIM35-20,ZFP668 |
| phosphoglycolate phosphatase activity | PGP |
| damaged DNA binding | POLH,NEIL2,RAD23A,TP63,H2AFX,TRPC2,NEIL1,XRCC1,XPA,TP73 |
| chromatin binding | RBMX,CREB3,NUP62,HMGB1,PRIMPOL,SNAI2,SP140L,EZH2,TCF7L1A,MTA1 |
| double-stranded RNA binding | TLR3,SUPV3L1,DHX36,SLC3A2,EIF2C3,DGCR8,STAU2,ILF2,OAS1B,AGO2 |
| polynucleotide 3-phosphatase activity | PNKP |
Interacting Protein
APTX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APTX here. Most of them are supplied by our site. Hope this information will be useful for your research of APTX.
XRCC1;XRCC4
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